tetano
Editor, Senior Moderator
PLoS One
. 2020 Nov 12;15(11):e0242307.
doi: 10.1371/journal.pone.0242307. eCollection 2020.
Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020
Sijiao Wang[SUP] 1 2 [/SUP], Zhisheng Chen[SUP] 1 [/SUP], Yijian Lin[SUP] 3 [/SUP], Li Lin[SUP] 4 [/SUP], Qunying Lin[SUP] 5 [/SUP], Sufang Fang[SUP] 6 [/SUP], Yonghong Shi[SUP] 7 [/SUP], Xibin Zhuang[SUP] 3 [/SUP], Yuming Ye[SUP] 4 [/SUP], Ting Wang[SUP] 6 [/SUP], Hongying Zhang[SUP] 6 [/SUP], Changzhou Shao[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.
Methods: In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical.
Results: Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19.
Conclusions: Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.
. 2020 Nov 12;15(11):e0242307.
doi: 10.1371/journal.pone.0242307. eCollection 2020.
Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020
Sijiao Wang[SUP] 1 2 [/SUP], Zhisheng Chen[SUP] 1 [/SUP], Yijian Lin[SUP] 3 [/SUP], Li Lin[SUP] 4 [/SUP], Qunying Lin[SUP] 5 [/SUP], Sufang Fang[SUP] 6 [/SUP], Yonghong Shi[SUP] 7 [/SUP], Xibin Zhuang[SUP] 3 [/SUP], Yuming Ye[SUP] 4 [/SUP], Ting Wang[SUP] 6 [/SUP], Hongying Zhang[SUP] 6 [/SUP], Changzhou Shao[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33180862
- DOI: 10.1371/journal.pone.0242307
Abstract
Background: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.
Methods: In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical.
Results: Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19.
Conclusions: Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.