tetano
Editor, Senior Moderator
PLoS Comput Biol
. 2021 Jan 29;17(1):e1008679.
doi: 10.1371/journal.pcbi.1008679. Online ahead of print.
Estimating the time-varying reproduction number of COVID-19 with a state-space method
Shinsuke Koyama[SUP] 1 [/SUP], Taiki Horie[SUP] 2 [/SUP], Shigeru Shinomoto[SUP] 2 3 [/SUP]
Affiliations
Abstract
After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the face of critical damage to socioeconomic structures. At this stage, it is desirable to monitor the degree to which political measures or social affairs have exerted influence on the spread of disease. Though it is difficult to trace back individual transmission of infections whose incubation periods are long and highly variable, estimating the average spreading rate is possible if a proper mathematical model can be devised to analyze daily event-occurrences. To render an accurate assessment, we have devised a state-space method for fitting a discrete-time variant of the Hawkes process to a given dataset of daily confirmed cases. The proposed method detects changes occurring in each country and assesses the impact of social events in terms of the temporally varying reproduction number, which corresponds to the average number of cases directly caused by a single infected case. Moreover, the proposed method can be used to predict the possible consequences of alternative political measures. This information can serve as a reference for behavioral guidelines that should be adopted according to the varying risk of infection.
. 2021 Jan 29;17(1):e1008679.
doi: 10.1371/journal.pcbi.1008679. Online ahead of print.
Estimating the time-varying reproduction number of COVID-19 with a state-space method
Shinsuke Koyama[SUP] 1 [/SUP], Taiki Horie[SUP] 2 [/SUP], Shigeru Shinomoto[SUP] 2 3 [/SUP]
Affiliations
- PMID: 33513137
- DOI: 10.1371/journal.pcbi.1008679
Abstract
After slowing down the spread of the novel coronavirus COVID-19, many countries have started to relax their confinement measures in the face of critical damage to socioeconomic structures. At this stage, it is desirable to monitor the degree to which political measures or social affairs have exerted influence on the spread of disease. Though it is difficult to trace back individual transmission of infections whose incubation periods are long and highly variable, estimating the average spreading rate is possible if a proper mathematical model can be devised to analyze daily event-occurrences. To render an accurate assessment, we have devised a state-space method for fitting a discrete-time variant of the Hawkes process to a given dataset of daily confirmed cases. The proposed method detects changes occurring in each country and assesses the impact of social events in terms of the temporally varying reproduction number, which corresponds to the average number of cases directly caused by a single infected case. Moreover, the proposed method can be used to predict the possible consequences of alternative political measures. This information can serve as a reference for behavioral guidelines that should be adopted according to the varying risk of infection.