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PLoS Biol . New transcription signals in SARS-CoV-2 reshape virus-host interactions

tetano

tetano

Editor, Senior Moderator
PLoS Biol


. 2026 Apr 17;24(4):e3003744.
doi: 10.1371/journal.pbio.3003744. eCollection 2026 Apr.
New transcription signals in SARS-CoV-2 reshape virus-host interactions

Isabel Sola[SUP] 1 [/SUP], Sonia Zuñiga[SUP] 1 [/SUP]


Affiliations
Abstract

Non-spike changes driving SARS-CoV-2 fitness remain undercharacterized. Two PLOS Biology papers show that evolutionary N gene changes create a transcription-regulating sequence producing a truncated N protein that enhances fitness by blocking antiviral responses.


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