tetano
Editor, Senior Moderator
Microbiol Immunol. 2012 Jan 25. doi: 10.1111/j.1348-0421.2011.00432.x. [Epub ahead of print]
Phylogenetic analyses of pandemic influenza A (H1N1) virus in university students at Tobetsu, Hokkaido, Japan.
Inoue E, Ieko M, Takahashi N, Osawa Y, Okazaki K.
Source
Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Japan, Department of Internal Medicine, Faculty of Dentistry, Japan, and Division of Medical Science, The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
Abstract
Pandemic influenza (H1N1) virus [A(H1N1)pdm09] emerged in 2009. To determine the phylogeography of A(H1N1)pdm09 in a single population, a total of 70 strains of the virus were isolated from university students or trainee doctors at Tobetsu, Hokkaido, Japan, between September and December 2009. We analyzed nucleotide sequences of HA1 region of the HA genes and described phylogenetic relationships of the strains circulating among them. The results indicate that the 70 isolates could be phylogenetically separated into three groups and that two epidemics were caused by different groups of the virus. The three groups were also distinguished from each other by three amino acid changes: A197T, S203T and Q293H. The substitution of S203T, which located in the antigenic site, suggests antigenic drift of the virus.
? 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID:
22277047
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22277047
Phylogenetic analyses of pandemic influenza A (H1N1) virus in university students at Tobetsu, Hokkaido, Japan.
Inoue E, Ieko M, Takahashi N, Osawa Y, Okazaki K.
Source
Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Japan, Department of Internal Medicine, Faculty of Dentistry, Japan, and Division of Medical Science, The Research Institute of Personalized Health Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan.
Abstract
Pandemic influenza (H1N1) virus [A(H1N1)pdm09] emerged in 2009. To determine the phylogeography of A(H1N1)pdm09 in a single population, a total of 70 strains of the virus were isolated from university students or trainee doctors at Tobetsu, Hokkaido, Japan, between September and December 2009. We analyzed nucleotide sequences of HA1 region of the HA genes and described phylogenetic relationships of the strains circulating among them. The results indicate that the 70 isolates could be phylogenetically separated into three groups and that two epidemics were caused by different groups of the virus. The three groups were also distinguished from each other by three amino acid changes: A197T, S203T and Q293H. The substitution of S203T, which located in the antigenic site, suggests antigenic drift of the virus.
? 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
PMID:
22277047
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22277047