tetano
Editor, Senior Moderator
Pharmacol Res
. 2020 May 22;104946.
doi: 10.1016/j.phrs.2020.104946. Online ahead of print.
Biochemical Indicators of Coronavirus Disease 2019 Exacerbation and the Clinical Implications
Peng-Jiao An[SUP] 1 [/SUP], Zhun Zhu Yi[SUP] 2 [/SUP], Li-Ping Yang[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus Disease 2019 (COVID-19) has sparked a global pandemic, affecting more than 4 million people worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute lung injury (ALI) and even acute respiratory distress syndrome (ARDS); with a fatality of 7.0 %. Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Furthermore, secondary bacterial infection may contribute to the exacerbation of COVID-19. We recommend using both IL-10 and IL-6 as the indicators of cytokine storm, and monitoring the elevation of procalcitonin (PCT) as an alert for initiating antibacterial agents. Understanding the dynamic progression of SARS-CoV-2 infection is crucial to determine an effective treatment strategy to reduce the rising mortality of this global pandemic.
Keywords: Coronavirus; Cytokine storm; Immune escape; Inflammation; SARS-CoV-2.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
. 2020 May 22;104946.
doi: 10.1016/j.phrs.2020.104946. Online ahead of print.
Biochemical Indicators of Coronavirus Disease 2019 Exacerbation and the Clinical Implications
Peng-Jiao An[SUP] 1 [/SUP], Zhun Zhu Yi[SUP] 2 [/SUP], Li-Ping Yang[SUP] 3 [/SUP]
Affiliations
- PMID: 32450346
- DOI: 10.1016/j.phrs.2020.104946
Abstract
Coronavirus Disease 2019 (COVID-19) has sparked a global pandemic, affecting more than 4 million people worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute lung injury (ALI) and even acute respiratory distress syndrome (ARDS); with a fatality of 7.0 %. Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Furthermore, secondary bacterial infection may contribute to the exacerbation of COVID-19. We recommend using both IL-10 and IL-6 as the indicators of cytokine storm, and monitoring the elevation of procalcitonin (PCT) as an alert for initiating antibacterial agents. Understanding the dynamic progression of SARS-CoV-2 infection is crucial to determine an effective treatment strategy to reduce the rising mortality of this global pandemic.
Keywords: Coronavirus; Cytokine storm; Immune escape; Inflammation; SARS-CoV-2.
Copyright ? 2020 Elsevier Ltd. All rights reserved.