tetano
Editor, Senior Moderator
Pediatrics. 2016 Jun 6. pii: e20160320. [Epub ahead of print]
[h=1]Febrile Seizure Risk After Vaccination in Children 6 to 23 Months.[/h] Duffy J[SUP]1[/SUP], Weintraub E[SUP]2[/SUP], Hambidge SJ[SUP]3[/SUP], Jackson LA[SUP]4[/SUP], Kharbanda EO[SUP]5[/SUP], Klein NP[SUP]6[/SUP], Lee GM[SUP]7[/SUP], Marcy SM[SUP]8[/SUP], Nakasato CC[SUP]9[/SUP], Naleway A[SUP]10[/SUP], Omer SB[SUP]11[/SUP], Vellozzi C[SUP]2[/SUP], DeStefano F[SUP]2[/SUP]; Vaccine Safety Datalink.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND OBJECTIVE:[/h] An increased risk of febrile seizure (FS) was identified with concomitant administration of trivalent inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) 13-valent during the 2010-2011 influenza season. Our objective was to determine whether concomitant administration of IIV3 with other vaccines affects the FS risk.
[h=4]METHODS:[/h] We examined the risk of FS 0 to 1 day postvaccination for all routinely recommended vaccines among children aged 6 through 23 months during a period encompassing 5 influenza seasons (2006-2007 through 2010-2011). We used a population-based self-controlled risk interval analysis with a control interval of 14 to 20 days postvaccination. We used multivariable regression to control for receipt of concomitant vaccines and test for interaction between vaccines.
[h=4]RESULTS:[/h] Only PCV 7-valent had an independent FS risk (incidence rate ratio [IRR], 1.98; 95% confidence interval [CI], 1.00 to 3.91). IIV3 had no independent risk (IRR, 0.46; 95% CI, 0.21 to 1.02), but risk was increased when IIV3 was given with either PCV (IRR, 3.50; 95% CI, 1.13 to 10.85) or a diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine (IRR, 3.50; 95% CI, 1.52 to 8.07). The maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines compared with administration on separate days was 30 FS per 100 000 persons vaccinated.
[h=4]CONCLUSIONS:[/h] The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day. The absolute risk of postvaccination FS with these vaccine combinations was small.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 27273711 [PubMed - as supplied by publisher]
[h=1]Febrile Seizure Risk After Vaccination in Children 6 to 23 Months.[/h] Duffy J[SUP]1[/SUP], Weintraub E[SUP]2[/SUP], Hambidge SJ[SUP]3[/SUP], Jackson LA[SUP]4[/SUP], Kharbanda EO[SUP]5[/SUP], Klein NP[SUP]6[/SUP], Lee GM[SUP]7[/SUP], Marcy SM[SUP]8[/SUP], Nakasato CC[SUP]9[/SUP], Naleway A[SUP]10[/SUP], Omer SB[SUP]11[/SUP], Vellozzi C[SUP]2[/SUP], DeStefano F[SUP]2[/SUP]; Vaccine Safety Datalink.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND AND OBJECTIVE:[/h] An increased risk of febrile seizure (FS) was identified with concomitant administration of trivalent inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) 13-valent during the 2010-2011 influenza season. Our objective was to determine whether concomitant administration of IIV3 with other vaccines affects the FS risk.
[h=4]METHODS:[/h] We examined the risk of FS 0 to 1 day postvaccination for all routinely recommended vaccines among children aged 6 through 23 months during a period encompassing 5 influenza seasons (2006-2007 through 2010-2011). We used a population-based self-controlled risk interval analysis with a control interval of 14 to 20 days postvaccination. We used multivariable regression to control for receipt of concomitant vaccines and test for interaction between vaccines.
[h=4]RESULTS:[/h] Only PCV 7-valent had an independent FS risk (incidence rate ratio [IRR], 1.98; 95% confidence interval [CI], 1.00 to 3.91). IIV3 had no independent risk (IRR, 0.46; 95% CI, 0.21 to 1.02), but risk was increased when IIV3 was given with either PCV (IRR, 3.50; 95% CI, 1.13 to 10.85) or a diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine (IRR, 3.50; 95% CI, 1.52 to 8.07). The maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines compared with administration on separate days was 30 FS per 100 000 persons vaccinated.
[h=4]CONCLUSIONS:[/h] The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day. The absolute risk of postvaccination FS with these vaccine combinations was small.
Copyright ? 2016 by the American Academy of Pediatrics.
PMID: 27273711 [PubMed - as supplied by publisher]