tetano
Editor, Senior Moderator
Pediatrics
. 2023 Oct 13:e2023062702.
doi: 10.1542/peds.2023-062702. Online ahead of print. Early Postnatal Infection of Neonates Born to Mothers Infected by SARS-CoV-2 Omicron Variant
Carlo Pietrasanta[SUP] #[/SUP][SUP] 1 2 [/SUP], Andrea Ronchi[SUP] #[/SUP][SUP] 1 [/SUP], Massimo Agosti[SUP] 3 4 [/SUP], Giovanna Mangili[SUP] 5 [/SUP], Mariateresa Sinelli[SUP] 6 [/SUP], Stefano Ghirardello[SUP] 1 [/SUP], Roberta Barachetti[SUP] 7 [/SUP], Riccardo Crimi[SUP] 1 2 [/SUP], Valeria Fasolato[SUP] 8 [/SUP], Stefano Martinelli[SUP] 9 [/SUP], Cristina Bellan[SUP] 10 [/SUP], Beatrice Crippa[SUP] 1 [/SUP], Giacomo Artieri[SUP] 1 2 [/SUP], Simona Perniciaro[SUP] 3 [/SUP], Martina Saruggia[SUP] 5 [/SUP], Maria Luisa Ventura[SUP] 6 [/SUP], Francesca Garofoli[SUP] 1 [/SUP], Claudia Pagliotta[SUP] 7 [/SUP], Sara Colonia Uceda Renteria[SUP] 11 [/SUP], Antonio Piralla[SUP] 12 [/SUP], Federica Bergami[SUP] 12 [/SUP], Grazia Morandi[SUP] 8 [/SUP], Alice Proto[SUP] 9 [/SUP], Federica Pontiggia[SUP] 10 [/SUP], Francesco Maria Risso[SUP] 13 [/SUP], Angela Bossi[SUP] 3 [/SUP], Stefania Ferrari[SUP] 5 [/SUP], Valeria Cavalleri[SUP] 6 [/SUP], Pierpaolo Servi[SUP] 1 [/SUP], Aurelia Castiglione[SUP] 7 [/SUP], Elena Spada[SUP] 1 14 [/SUP], Ferruccio Ceriotti[SUP] 11 [/SUP], Fausto Baldanti[SUP] 12 15 [/SUP], Fabio Mosca[SUP] 1 2 [/SUP], Lorenza Pugni[SUP] 1 [/SUP]
Affiliations
Objectives: To evaluate the rate of postnatal infection during the first month of life in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers during the predominant circulation of the omicron (B.1.1.529) variant.
Methods: This prospective, 10-center study enrolled mothers infected by SARS-CoV-2 at delivery and their infants, if both were eligible for rooming-in, between December 2021 and March 2022. Neonates were screened for SARS-CoV-2 RNA at 1 day of life (DOL), 2 to 3 DOL, before discharge, and twice after hospital discharge. Mother-infant dyads were managed under a standardized protocol to minimize the risk of viral transmission. Sequencing data in the study area were obtained from the Italian Coronavirus Disease 2019 Genomic platform. Neonates were included in the final analysis if they were born when the omicron variant represented >90% of isolates.
Results: Eighty-two percent (302/366) of mothers had an asymptomatic SARS-CoV-2 infection. Among 368 neonates, 1 was considered infected in utero (0.3%), whereas the postnatal infection rate during virtually exclusive circulation of the omicron variant was 12.1%. Among neonates infected after birth, 48.6% became positive during the follow-up period. Most positive cases at follow-up were detected concurrently with the peak of coronavirus disease 2019 cases in Italy. Ninety-seven percent of the infected neonates were asymptomatic.
Conclusions: The risk of early postnatal infection by the SARS-CoV-2 omicron variant is higher than that reported for previously circulating variants. However, protected rooming-in practice should still be encouraged given the paucity of symptoms in infected neonates.
. 2023 Oct 13:e2023062702.
doi: 10.1542/peds.2023-062702. Online ahead of print. Early Postnatal Infection of Neonates Born to Mothers Infected by SARS-CoV-2 Omicron Variant
Carlo Pietrasanta[SUP] #[/SUP][SUP] 1 2 [/SUP], Andrea Ronchi[SUP] #[/SUP][SUP] 1 [/SUP], Massimo Agosti[SUP] 3 4 [/SUP], Giovanna Mangili[SUP] 5 [/SUP], Mariateresa Sinelli[SUP] 6 [/SUP], Stefano Ghirardello[SUP] 1 [/SUP], Roberta Barachetti[SUP] 7 [/SUP], Riccardo Crimi[SUP] 1 2 [/SUP], Valeria Fasolato[SUP] 8 [/SUP], Stefano Martinelli[SUP] 9 [/SUP], Cristina Bellan[SUP] 10 [/SUP], Beatrice Crippa[SUP] 1 [/SUP], Giacomo Artieri[SUP] 1 2 [/SUP], Simona Perniciaro[SUP] 3 [/SUP], Martina Saruggia[SUP] 5 [/SUP], Maria Luisa Ventura[SUP] 6 [/SUP], Francesca Garofoli[SUP] 1 [/SUP], Claudia Pagliotta[SUP] 7 [/SUP], Sara Colonia Uceda Renteria[SUP] 11 [/SUP], Antonio Piralla[SUP] 12 [/SUP], Federica Bergami[SUP] 12 [/SUP], Grazia Morandi[SUP] 8 [/SUP], Alice Proto[SUP] 9 [/SUP], Federica Pontiggia[SUP] 10 [/SUP], Francesco Maria Risso[SUP] 13 [/SUP], Angela Bossi[SUP] 3 [/SUP], Stefania Ferrari[SUP] 5 [/SUP], Valeria Cavalleri[SUP] 6 [/SUP], Pierpaolo Servi[SUP] 1 [/SUP], Aurelia Castiglione[SUP] 7 [/SUP], Elena Spada[SUP] 1 14 [/SUP], Ferruccio Ceriotti[SUP] 11 [/SUP], Fausto Baldanti[SUP] 12 15 [/SUP], Fabio Mosca[SUP] 1 2 [/SUP], Lorenza Pugni[SUP] 1 [/SUP]
Affiliations
- PMID: 37830167
- DOI: 10.1542/peds.2023-062702
Objectives: To evaluate the rate of postnatal infection during the first month of life in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers during the predominant circulation of the omicron (B.1.1.529) variant.
Methods: This prospective, 10-center study enrolled mothers infected by SARS-CoV-2 at delivery and their infants, if both were eligible for rooming-in, between December 2021 and March 2022. Neonates were screened for SARS-CoV-2 RNA at 1 day of life (DOL), 2 to 3 DOL, before discharge, and twice after hospital discharge. Mother-infant dyads were managed under a standardized protocol to minimize the risk of viral transmission. Sequencing data in the study area were obtained from the Italian Coronavirus Disease 2019 Genomic platform. Neonates were included in the final analysis if they were born when the omicron variant represented >90% of isolates.
Results: Eighty-two percent (302/366) of mothers had an asymptomatic SARS-CoV-2 infection. Among 368 neonates, 1 was considered infected in utero (0.3%), whereas the postnatal infection rate during virtually exclusive circulation of the omicron variant was 12.1%. Among neonates infected after birth, 48.6% became positive during the follow-up period. Most positive cases at follow-up were detected concurrently with the peak of coronavirus disease 2019 cases in Italy. Ninety-seven percent of the infected neonates were asymptomatic.
Conclusions: The risk of early postnatal infection by the SARS-CoV-2 omicron variant is higher than that reported for previously circulating variants. However, protected rooming-in practice should still be encouraged given the paucity of symptoms in infected neonates.