tetano
Editor, Senior Moderator
Pediatrics
. 2020 Jul 27;e20200375.
doi: 10.1542/peds.2020-0375. Online ahead of print.
Early Childhood Health Outcomes Following In Utero Exposure to Influenza Vaccines: A Systematic Review
Damien Y P Foo[SUP] 1 2 [/SUP], Mohinder Sarna[SUP] 3 2 [/SUP], Gavin Pereira[SUP] 3 4 5 [/SUP], Hannah C Moore[SUP] 2 [/SUP], Deshayne B Fell[SUP] 6 7 [/SUP], Annette K Regan[SUP] 3 2 8 [/SUP]
Affiliations
Abstract
Context: Vaccination during pregnancy is an effective strategy for preventing infant disease; however, little is known about early childhood health after maternal vaccination.
Objectives: To systematically review the literature on early childhood health associated with exposure to influenza vaccines in utero.
Data sources: We searched CINAHL Plus, Embase, Medline, Scopus, and Web of Science for relevant articles published from inception to July 24, 2019.
Study selection: We included studies published in English reporting original data with measurement of in utero exposure to influenza vaccines and health outcomes among children <5 years of age.
Data extraction: Two authors independently assessed eligibility and extracted data on study design, setting, population, vaccines, outcomes, and results.
Results: The search yielded 3647 records, of which 9 studies met the inclusion criteria. Studies examined infectious, atopic, autoimmune, and neurodevelopmental outcomes, and all-cause morbidity and mortality. Authors of 2 studies reported an inverse association between pandemic influenza vaccination and upper respiratory tract infections and all-cause hospitalizations, and authors of 2 studies reported modest increased association between several childhood disorders and pandemic or seasonal influenza vaccination, which, after adjusting for confounding and multiple comparisons, were not statistically significant.
Limitations: Given the small number of studies addressing similarly defined outcomes, meta-analyses were deemed not possible.
Conclusions: Results from the few studies in which researchers have examined outcomes in children older than 6 months of age did not identify an association between exposure to influenza vaccines in utero and adverse childhood health outcomes.
. 2020 Jul 27;e20200375.
doi: 10.1542/peds.2020-0375. Online ahead of print.
Early Childhood Health Outcomes Following In Utero Exposure to Influenza Vaccines: A Systematic Review
Damien Y P Foo[SUP] 1 2 [/SUP], Mohinder Sarna[SUP] 3 2 [/SUP], Gavin Pereira[SUP] 3 4 5 [/SUP], Hannah C Moore[SUP] 2 [/SUP], Deshayne B Fell[SUP] 6 7 [/SUP], Annette K Regan[SUP] 3 2 8 [/SUP]
Affiliations
- PMID: 32719088
- DOI: 10.1542/peds.2020-0375
Abstract
Context: Vaccination during pregnancy is an effective strategy for preventing infant disease; however, little is known about early childhood health after maternal vaccination.
Objectives: To systematically review the literature on early childhood health associated with exposure to influenza vaccines in utero.
Data sources: We searched CINAHL Plus, Embase, Medline, Scopus, and Web of Science for relevant articles published from inception to July 24, 2019.
Study selection: We included studies published in English reporting original data with measurement of in utero exposure to influenza vaccines and health outcomes among children <5 years of age.
Data extraction: Two authors independently assessed eligibility and extracted data on study design, setting, population, vaccines, outcomes, and results.
Results: The search yielded 3647 records, of which 9 studies met the inclusion criteria. Studies examined infectious, atopic, autoimmune, and neurodevelopmental outcomes, and all-cause morbidity and mortality. Authors of 2 studies reported an inverse association between pandemic influenza vaccination and upper respiratory tract infections and all-cause hospitalizations, and authors of 2 studies reported modest increased association between several childhood disorders and pandemic or seasonal influenza vaccination, which, after adjusting for confounding and multiple comparisons, were not statistically significant.
Limitations: Given the small number of studies addressing similarly defined outcomes, meta-analyses were deemed not possible.
Conclusions: Results from the few studies in which researchers have examined outcomes in children older than 6 months of age did not identify an association between exposure to influenza vaccines in utero and adverse childhood health outcomes.