tetano
Editor, Senior Moderator
Pediatrics
. 2025 Apr 2:e2024068064.
doi: 10.1542/peds.2024-068064. Online ahead of print. 11-Year-Old Boy With B-ALL-Induced Hypereosinophilic Syndrome Presenting as Acute Encephalopathy
Tristan Loveday[SUP] 1 [/SUP], Cintia da Hora[SUP] 1 2 [/SUP], Rudolph Wells[SUP] 3 4 [/SUP], Lauren Chorny[SUP] 1 2 [/SUP], Manisha Bansal[SUP] 1 3 4 [/SUP], Scott Bradfield[SUP] 3 4 [/SUP], Loren McLendon[SUP] 1 2 [/SUP]
Affiliations
Encephalopathy is a disturbance in neurologic function. It is commonly attributed to infectious and inflammatory etiologies but encompasses a wide differential. Hypereosinophilic syndrome (HES) is a rare cause of encephalopathy that is associated with underlying infection or malignancy. We present a pediatric patient who experienced several days of worsening encephalopathy and neurological deterioration associated with influenza B infection and hypereosinophilia. A thorough workup ultimately revealed a diagnosis of HES secondary to B cell acute lymphoblastic leukemia (B-ALL). This case exemplifies the importance of maintaining a broad approach to the diagnostic evaluation, treatment, and management of encephalopathy.
. 2025 Apr 2:e2024068064.
doi: 10.1542/peds.2024-068064. Online ahead of print. 11-Year-Old Boy With B-ALL-Induced Hypereosinophilic Syndrome Presenting as Acute Encephalopathy
Tristan Loveday[SUP] 1 [/SUP], Cintia da Hora[SUP] 1 2 [/SUP], Rudolph Wells[SUP] 3 4 [/SUP], Lauren Chorny[SUP] 1 2 [/SUP], Manisha Bansal[SUP] 1 3 4 [/SUP], Scott Bradfield[SUP] 3 4 [/SUP], Loren McLendon[SUP] 1 2 [/SUP]
Affiliations
- PMID: 40169155
- DOI: 10.1542/peds.2024-068064
Encephalopathy is a disturbance in neurologic function. It is commonly attributed to infectious and inflammatory etiologies but encompasses a wide differential. Hypereosinophilic syndrome (HES) is a rare cause of encephalopathy that is associated with underlying infection or malignancy. We present a pediatric patient who experienced several days of worsening encephalopathy and neurological deterioration associated with influenza B infection and hypereosinophilia. A thorough workup ultimately revealed a diagnosis of HES secondary to B cell acute lymphoblastic leukemia (B-ALL). This case exemplifies the importance of maintaining a broad approach to the diagnostic evaluation, treatment, and management of encephalopathy.