tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2021 May 7.
doi: 10.1097/INF.0000000000003146. Online ahead of print.
First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barr? Syndrome
Naiana Mota Ara?jo[SUP] 1 [/SUP], Lis Campos Ferreira, D?bora Para?so Dantas, Denison Santos Silva, Cliomar Alves Dos Santos, Rosana Cipolotti, Paulo Ricardo Martins-Filho
Affiliations
Abstract
Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications are still poorly understood. Cases of Guillain-Barr? Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.
. 2021 May 7.
doi: 10.1097/INF.0000000000003146. Online ahead of print.
First Report of SARS-CoV-2 Detection in Cerebrospinal Fluid in a Child With Guillain-Barr? Syndrome
Naiana Mota Ara?jo[SUP] 1 [/SUP], Lis Campos Ferreira, D?bora Para?so Dantas, Denison Santos Silva, Cliomar Alves Dos Santos, Rosana Cipolotti, Paulo Ricardo Martins-Filho
Affiliations
- PMID: 33990525
- DOI: 10.1097/INF.0000000000003146
Abstract
Underlying mechanisms on the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurological complications are still poorly understood. Cases of Guillain-Barr? Syndrome (GBS) have been linked to the SARS-CoV-2 infection as the result of dysregulated immune response with damage in neuronal tissues. In the current report, we present the first pediatric case of GBS with detection of SARS-CoV-2 in the cerebrospinal fluid (CFS). This unique case of COVID-19-associated GBS with detection of SARS-CoV-2 RNA in the CSF indicates direct viral involvement inducing peripheral nerve inflammation.