tetano
Editor, Senior Moderator
Pediatr Infect Dis J
. 2021 Mar 9.
doi: 10.1097/INF.0000000000003124. Online ahead of print.
Concurrent Longitudinally Extensive Transverse Myelitis and Guillain-Barr? Syndrome in a Child Secondary to COVID-19 Infection: A Severe Neuroimmunologic Complication of COVID-19
Daisy Khera[SUP] 1 [/SUP], Siyaram Didel, Samhita Panda, Sarbesh Tiwari, Kuldeep Singh
Affiliations
Abstract
Neurologic manifestation of coronavirus disease 2019 (COVID-19) in children is evolving with time. We are reporting a young girl who presented to us with acute febrile illness followed by acute onset severe flaccid paralysis requiring prolonged intensive care unit stay and ventilator support. She was evaluated extensively and found to be positive for COVID serology, and neuroimaging revealed features of longitudinally extensive transverse myelitis (LETM) with enhancing cauda equina nerve roots, suggesting Guillain-Barr? Syndrome (GBS). She failed to respond to immune suppressive therapy and needed plasma exchange for recovery. Like other common viral illnesses, COVID-19 can also act as a trigger for GBS-like illness and LETM, and we need to suspect these diagnoses in the cases with COVID-19 infection in compatible cases. This is probably the first pediatric case with concurrent GBS and LETM secondary to COVID-19 infection.
. 2021 Mar 9.
doi: 10.1097/INF.0000000000003124. Online ahead of print.
Concurrent Longitudinally Extensive Transverse Myelitis and Guillain-Barr? Syndrome in a Child Secondary to COVID-19 Infection: A Severe Neuroimmunologic Complication of COVID-19
Daisy Khera[SUP] 1 [/SUP], Siyaram Didel, Samhita Panda, Sarbesh Tiwari, Kuldeep Singh
Affiliations
- PMID: 33902076
- DOI: 10.1097/INF.0000000000003124
Abstract
Neurologic manifestation of coronavirus disease 2019 (COVID-19) in children is evolving with time. We are reporting a young girl who presented to us with acute febrile illness followed by acute onset severe flaccid paralysis requiring prolonged intensive care unit stay and ventilator support. She was evaluated extensively and found to be positive for COVID serology, and neuroimaging revealed features of longitudinally extensive transverse myelitis (LETM) with enhancing cauda equina nerve roots, suggesting Guillain-Barr? Syndrome (GBS). She failed to respond to immune suppressive therapy and needed plasma exchange for recovery. Like other common viral illnesses, COVID-19 can also act as a trigger for GBS-like illness and LETM, and we need to suspect these diagnoses in the cases with COVID-19 infection in compatible cases. This is probably the first pediatric case with concurrent GBS and LETM secondary to COVID-19 infection.