tetano
Editor, Senior Moderator
Clin Dev Immunol. 2013;2013:989673. doi: 10.1155/2013/989673. Epub 2013 Sep 26.
PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response.
Valero-Pacheco N, Arriaga-Pizano L, Ferat-Osorio E, Mora-Velandia LM, Pastelin-Palacios R, Villas?s-Keever M?, Alpuche-Aranda C, S?nchez-Torres LE, Isibasi A, Bonifaz L, L?pez-Mac?as C.
Source
Medical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre "Siglo XXI," Mexican Social Security Institute (IMSS), 06720 M?xico, DF, Mexico ; Departamento de Inmunolog?a, Escuela Nacional de Ciencias Biol?gicas, Instituto Polit?cnico Nacional, 11340 M?xico, DF, Mexico.
Abstract
PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8(+) T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8(+) T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
PMID:
24187568
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24187568
PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response.
Valero-Pacheco N, Arriaga-Pizano L, Ferat-Osorio E, Mora-Velandia LM, Pastelin-Palacios R, Villas?s-Keever M?, Alpuche-Aranda C, S?nchez-Torres LE, Isibasi A, Bonifaz L, L?pez-Mac?as C.
Source
Medical Research Unit on Immunochemistry (UIMIQ), Specialties Hospital, National Medical Centre "Siglo XXI," Mexican Social Security Institute (IMSS), 06720 M?xico, DF, Mexico ; Departamento de Inmunolog?a, Escuela Nacional de Ciencias Biol?gicas, Instituto Polit?cnico Nacional, 11340 M?xico, DF, Mexico.
Abstract
PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-L1 on T cells during acute viral infections, particularly during the pandemic influenza virus (A(H1N1)pdm09), and its effects on the T cell response have not been widely explored. We found that A(H1N1)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(H1N1)pdm09 by promoting CD8(+) T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8(+) T cells correlated inversely with T cell proportions in patients infected with A(H1N1)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(H1N1)pdm09 virus.
PMID:
24187568
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/24187568