tetano
Editor, Senior Moderator
Pathol Res Pract
. 2021 Oct 12;228:153647.
doi: 10.1016/j.prp.2021.153647. Online ahead of print.
Host factors: Implications in immunopathogenesis of COVID-19
Roghayeh Jafarpour[SUP] 1 [/SUP], Salar Pashangzadeh[SUP] 2 [/SUP], Razieh Dowran[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients' situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia.
Keywords: ACE2; COVID-19; Genetic susceptibility; Polymorphisms; SARS-CoV-2.
. 2021 Oct 12;228:153647.
doi: 10.1016/j.prp.2021.153647. Online ahead of print.
Host factors: Implications in immunopathogenesis of COVID-19
Roghayeh Jafarpour[SUP] 1 [/SUP], Salar Pashangzadeh[SUP] 2 [/SUP], Razieh Dowran[SUP] 3 [/SUP]
Affiliations
- PMID: 34749207
- DOI: 10.1016/j.prp.2021.153647
Abstract
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is more serious in people with underlying diseases, but the cause of healthy people with progressive disease is largely unknown. Host genetic factors such as ACE2 variants, IFITM-3, HLA, TMRSS2, and furin polymorphisms appear to be one of the agents involved in the progression of the COVID-19 and outcome of the disease. This review discusses the general characteristics of SARS-CoV-2, including viral features, receptors, cell entry, clinical findings, and the main human genetic factors that may contribute to the pathogenesis of COVID-19 and get the patients' situation more complex. Further knowledge in this context may help to find a way to prevent and treat this viral pneumonia.
Keywords: ACE2; COVID-19; Genetic susceptibility; Polymorphisms; SARS-CoV-2.