tetano
Editor, Senior Moderator
Pathogens
. 2021 Feb 8;10(2):180.
doi: 10.3390/pathogens10020180.
Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface
Hayden D Hedman[SUP] 1 [/SUP], Eric Krawczyk[SUP] 2 [/SUP], Yosra A Helmy[SUP] 3 [/SUP], Lixin Zhang[SUP] 4 5 [/SUP], Csaba Varga[SUP] 6 [/SUP]
Affiliations
Abstract
Emerging infectious diseases present great risks to public health. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become an urgent public health issue of global concern. It is speculated that the virus first emerged through a zoonotic spillover. Basic research studies have suggested that bats are likely the ancestral reservoir host. Nonetheless, the evolutionary history and host susceptibility of SARS-CoV-2 remains unclear as a multitude of animals has been proposed as potential intermediate or dead-end hosts. SARS-CoV-2 has been isolated from domestic animals, both companion and livestock, as well as in captive wildlife that were in close contact with human COVID-19 cases. Currently, domestic mink is the only known animal that is susceptible to a natural infection, develop severe illness, and can also transmit SARS-CoV-2 to other minks and humans. To improve foundational knowledge of SARS-CoV-2, we are conducting a synthesis review of its host diversity and transmission pathways. To mitigate this COVID-19 pandemic, we strongly advocate for a systems-oriented scientific approach that comprehensively evaluates the transmission of SARS-CoV-2 at the human and animal interface.
Keywords: COVID-19; One Health; SARS-CoV-2; animals; coronavirus; host diversity; humans.
. 2021 Feb 8;10(2):180.
doi: 10.3390/pathogens10020180.
Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface
Hayden D Hedman[SUP] 1 [/SUP], Eric Krawczyk[SUP] 2 [/SUP], Yosra A Helmy[SUP] 3 [/SUP], Lixin Zhang[SUP] 4 5 [/SUP], Csaba Varga[SUP] 6 [/SUP]
Affiliations
- PMID: 33567598
- DOI: 10.3390/pathogens10020180
Abstract
Emerging infectious diseases present great risks to public health. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has become an urgent public health issue of global concern. It is speculated that the virus first emerged through a zoonotic spillover. Basic research studies have suggested that bats are likely the ancestral reservoir host. Nonetheless, the evolutionary history and host susceptibility of SARS-CoV-2 remains unclear as a multitude of animals has been proposed as potential intermediate or dead-end hosts. SARS-CoV-2 has been isolated from domestic animals, both companion and livestock, as well as in captive wildlife that were in close contact with human COVID-19 cases. Currently, domestic mink is the only known animal that is susceptible to a natural infection, develop severe illness, and can also transmit SARS-CoV-2 to other minks and humans. To improve foundational knowledge of SARS-CoV-2, we are conducting a synthesis review of its host diversity and transmission pathways. To mitigate this COVID-19 pandemic, we strongly advocate for a systems-oriented scientific approach that comprehensively evaluates the transmission of SARS-CoV-2 at the human and animal interface.
Keywords: COVID-19; One Health; SARS-CoV-2; animals; coronavirus; host diversity; humans.