tetano
Editor, Senior Moderator
Microbiol Immunol. 2016 Feb 25. doi: 10.1111/1348-0421.12369. [Epub ahead of print]
[h=1]Pathogenicity of H5N8 highly pathogenic avian influenza viruses isolated from a wild bird fecal specimen and a chicken in Japan in 2014.[/h] Tanikawa T[SUP]1[/SUP], Kanehira K[SUP]1[/SUP], Tsunekuni R[SUP]1[/SUP], Uchida Y[SUP]1[/SUP], Takemae N[SUP]1[/SUP], Saito T[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Poultry outbreaks caused by H5N8 highly pathogenic avian influenza viruses (HPAIVs) occurred in Japan between December 2014 and January 2015. In the same period, H5N8 HPAIVs were isolated from wild birds and the environment in Japan. The hemagglutinin (HA) genes of these isolates were revealed to belong to clade 2.3.4.4, and they were distinguishable as three sub-groups within the clade. All of the Japanese isolates from poultry outbreaks belonged to one sub-group, whereas wild bird isolates belonged to different sub-groups. To examine whether the difference of pathogenicity to chickens between isolates of different HA sub-groups of clade 2.3.4.4 could explain why the Japanese poultry outbreaks were only caused by a particular sub-group, pathogenicities of A/chicken/Miyazaki/7/2014 (Miyazaki2014; sub-group C) and A/duck/Chiba/26-372-48/2014 (Chiba2014; sub-group A) to chickens were compared. As a result, the lethality of Miyazaki2014 in chickens was lower than that of Chiba2014, according to 50% chicken lethal dose (CLD[SUB]50[/SUB] ). This indicated that differences in pathogenicity may not be the reason why the Japanese poultry outbreaks only involved group C isolates.
? 2016 The Societies and John Wiley & Sons Australia, Ltd.
[h=4]KEYWORDS:[/h] Animal RNA virus; Chicken; H5N8 subtype highly pathogenic avian influenza; Pathogenicity; Wild bird
PMID: 26916882 [PubMed - as supplied by publisher]
[h=1]Pathogenicity of H5N8 highly pathogenic avian influenza viruses isolated from a wild bird fecal specimen and a chicken in Japan in 2014.[/h] Tanikawa T[SUP]1[/SUP], Kanehira K[SUP]1[/SUP], Tsunekuni R[SUP]1[/SUP], Uchida Y[SUP]1[/SUP], Takemae N[SUP]1[/SUP], Saito T[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Poultry outbreaks caused by H5N8 highly pathogenic avian influenza viruses (HPAIVs) occurred in Japan between December 2014 and January 2015. In the same period, H5N8 HPAIVs were isolated from wild birds and the environment in Japan. The hemagglutinin (HA) genes of these isolates were revealed to belong to clade 2.3.4.4, and they were distinguishable as three sub-groups within the clade. All of the Japanese isolates from poultry outbreaks belonged to one sub-group, whereas wild bird isolates belonged to different sub-groups. To examine whether the difference of pathogenicity to chickens between isolates of different HA sub-groups of clade 2.3.4.4 could explain why the Japanese poultry outbreaks were only caused by a particular sub-group, pathogenicities of A/chicken/Miyazaki/7/2014 (Miyazaki2014; sub-group C) and A/duck/Chiba/26-372-48/2014 (Chiba2014; sub-group A) to chickens were compared. As a result, the lethality of Miyazaki2014 in chickens was lower than that of Chiba2014, according to 50% chicken lethal dose (CLD[SUB]50[/SUB] ). This indicated that differences in pathogenicity may not be the reason why the Japanese poultry outbreaks only involved group C isolates.
? 2016 The Societies and John Wiley & Sons Australia, Ltd.
[h=4]KEYWORDS:[/h] Animal RNA virus; Chicken; H5N8 subtype highly pathogenic avian influenza; Pathogenicity; Wild bird
PMID: 26916882 [PubMed - as supplied by publisher]