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Pathogenic mechanisms of how human parvovirus breaks self-tolerance

Emily

Emily

Editor, Senior Moderator
https://jyx.jyu.fi/dspace/handle/123456789/54311
[h=1]Pathogenic mechanisms of how human parvovirus breaks self-tolerance[/h]

Name: 978-951-39-7115-1 ...
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[TABLE="class: ds-includeSet-table"]
[TR="class: ds-table-row even"]
[TD="class: label"]Title:[/TD]
[TD]Pathogenic mechanisms of how human parvovirus breaks self-tolerance[/TD]
[/TR]
[TR="class: ds-table-row odd"]
[TD="class: label"]Author:[/TD]
[TD]Puttaraksa, Kanoktip[/TD]
[/TR]
[TR="class: ds-table-row even"]
[TD="class: label"]Abstract:[/TD]
[TD]It is known that viral infections can cause acute, chronic, and autoimmune diseases (ADs). However, the mechanism of how a persistent viral infection contributes to ADs remains still unclear. In this thesis, pathological and immunological aspects of how common viruses can initiate autoimmunity were investigated, and human parvovirus B19 (B19V) was employed as a model virus. B19V non-structural protein 1 (NS1), a superfamily 3 (SF3) helicase, initiated DNA damage resulting in cellular apoptosis. The apoptotic bodies (ApoBods) induced by B19V NS1 were purified and characterized. These ApoBods contained viral NS1 proteins with modified autoimmune-associated self-antigens, e.g. DNA, Smith, Apolipoprotein H, and histone 4. Subsequently, in vitro B19V-induced ApoBods were phagocytized by macrophages that produced pro- inflammatory cytokines and chemokines such as sICAM-1, IL-8, TNF-Į, and IFN-Ȗ. Furthermore in vivo, the properties of viral-induced ApoBods causing immune ... [/TD]
[/TR]
[TR="class: ds-table-row odd"]
[TD="class: label"]ISBN:[/TD]
[TD]978-951-39-7115-1[/TD]
[/TR]
[TR="class: ds-table-row even"]
[TD="class: label"]Date:[/TD]
[TD]2017[/TD]
[/TR]
[TR="class: ds-table-row odd"]
[TD="class: label"]Belongs to series:[/TD]
[TD]Jyv?skyl? studies in biological and environmental science 330.[/TD]
[/TR]
[TR="class: ds-table-row even"]
[TD="class: label"]ISSN:[/TD]
[TD]1456-9701 Search the Publication Forum[/TD]
[/TR]
[TR="class: ds-table-row odd"]
[TD="class: label"]Subjects:[/TD]
[TD]autoimmunity apoptosis apoptotic bodies autoantibodies human parvovirus B19 non-structural protein 1 self-antigens virukset parvovirukset infektiot patogeneesi immunologia autoimmuniteetti ohjelmoitunut solukuolema vasta-aineet autovasta-aineet antigeenit[/TD]
[/TR]
[/TABLE]
Permanent link to this item: http://urn.fi/URN:ISBN:978-951-39-7115-1
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