tetano
Editor, Senior Moderator
Pathog Dis
. 2023 Oct 10:ftad028.
doi: 10.1093/femspd/ftad028. Online ahead of print. Oxidative profile, inflammatory responses and δ-aminolevulinate dehydratase enzyme activity in influenza B virus infection
Jovana Simonetti Bulegon[SUP] 1 [/SUP], Andressa de Azambuja Pias Weber[SUP] 1 [/SUP], Manoela Dias de Souza[SUP] 2 [/SUP], Fernanda Tibolla Viero[SUP] 3 [/SUP], Micheli Mainardi Pillat[SUP] 1 3 [/SUP], Thissiane de Lima Gonçalves[SUP] 1 2 [/SUP]
Affiliations
Background: determine the activity of the delta-aminolevulinate dehydratase (δ-ALA-D) enzyme, oxidative stress biomarkers and the expression of cytokines in those infected with influenza B virus (IBV).
Methods: to evaluate the activity of the δ-ALA-D enzyme, lipid peroxidation estimated as levels of thiobarbituric acid reactive substances (TBARS), protein (PSH), non-protein (NPSH) thiol groups, ferric reducing antioxidant power (FRAP), vitamin C concentration (VIT C) and cytokine levels in IBV infected individuals (n = 50) and a control group (n = 30).
Results: δ-ALA-D activity was significantly lower in IBV-infected compared to controls, as well as levels of thiols, vitamin C and FRAP. Lipid peroxidation and cytokine levels IL-6, IL-10, IL-17A and IFN-y were statistically higher in the IBV group.
Conclusion: we found evidenced of the generation of oxidants, the depletion of the antioxidant system, the decrease in the activity of the δ-ALA-D enzyme and the increase in the synthesis of cytokines, thus contributing to a better understanding of oxidative and inflammatory pathways during IBV infection.
Keywords: Oxidative stress; cytokines; influenza; sustained virologic response; viral infection.
. 2023 Oct 10:ftad028.
doi: 10.1093/femspd/ftad028. Online ahead of print. Oxidative profile, inflammatory responses and δ-aminolevulinate dehydratase enzyme activity in influenza B virus infection
Jovana Simonetti Bulegon[SUP] 1 [/SUP], Andressa de Azambuja Pias Weber[SUP] 1 [/SUP], Manoela Dias de Souza[SUP] 2 [/SUP], Fernanda Tibolla Viero[SUP] 3 [/SUP], Micheli Mainardi Pillat[SUP] 1 3 [/SUP], Thissiane de Lima Gonçalves[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37816669
- DOI: 10.1093/femspd/ftad028
Background: determine the activity of the delta-aminolevulinate dehydratase (δ-ALA-D) enzyme, oxidative stress biomarkers and the expression of cytokines in those infected with influenza B virus (IBV).
Methods: to evaluate the activity of the δ-ALA-D enzyme, lipid peroxidation estimated as levels of thiobarbituric acid reactive substances (TBARS), protein (PSH), non-protein (NPSH) thiol groups, ferric reducing antioxidant power (FRAP), vitamin C concentration (VIT C) and cytokine levels in IBV infected individuals (n = 50) and a control group (n = 30).
Results: δ-ALA-D activity was significantly lower in IBV-infected compared to controls, as well as levels of thiols, vitamin C and FRAP. Lipid peroxidation and cytokine levels IL-6, IL-10, IL-17A and IFN-y were statistically higher in the IBV group.
Conclusion: we found evidenced of the generation of oxidants, the depletion of the antioxidant system, the decrease in the activity of the δ-ALA-D enzyme and the increase in the synthesis of cytokines, thus contributing to a better understanding of oxidative and inflammatory pathways during IBV infection.
Keywords: Oxidative stress; cytokines; influenza; sustained virologic response; viral infection.