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Pandemic potential of avian influenza A (H7N9) viruses

tetano

tetano

Editor, Senior Moderator
Trends Microbiol. 2014 Sep 25. pii: S0966-842X(14)00179-6. doi: 10.1016/j.tim.2014.08.008. [Epub ahead of print]
Pandemic potential of avian influenza A (H7N9) viruses.
Watanabe T1, Watanabe S2, Maher EA3, Neumann G3, Kawaoka Y4.
Author information
Abstract

Avian influenza viruses rarely infect humans, but the recently emerged avian H7N9 influenza viruses have caused sporadic infections in humans in China, resulting in 440 confirmed cases with 122 fatalities as of 16 May 2014. In addition, epidemiologic surveys suggest that there have been asymptomatic or mild human infections with H7N9 viruses. These viruses replicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess mammalian-adapting amino acid changes that likely contribute to their ability to infect mammals. In this review, we summarize the characteristic features of the novel H7N9 viruses and assess their pandemic potential.

Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:

avian influenza H7N9 viruses; pandemic potential; transmission

PMID:
25264312
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25264312
 
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