tetano
Editor, Senior Moderator
Pancreatology
. 2022 Jan 25;S1424-3903(22)00009-6.
doi: 10.1016/j.pan.2022.01.008. Online ahead of print.
Virus related acute pancreatitis and virus superinfection in the 'Dual disease' model of acute pancreatitis and SARS-Co-V2 infection: A multicentre prospective study
Jayanta Samanta[SUP] 1 [/SUP], Soumya Jagannath Mahapatra[SUP] 2 [/SUP], Naveen Kumar[SUP] 1 [/SUP], Anshuman Elhence[SUP] 2 [/SUP], Jahnvi Dhar[SUP] 1 [/SUP], Anany Gupta[SUP] 2 [/SUP], Anugrah Dhooria[SUP] 2 [/SUP], Ashish Bhalla[SUP] 3 [/SUP], Manya Prasad[SUP] 4 [/SUP], Aritra Das[SUP] 5 [/SUP], Raju Sharma[SUP] 6 [/SUP], Rakesh Kochhar[SUP] 7 [/SUP], Pramod K Garg[SUP] 8 [/SUP], GAIN Study group
Collaborators, Affiliations
Abstract
Background: SARS-CoV-2 can cause acute pancreatitis (AP) and SARS-CoV-2 superinfection can occur in patients with AP during prolonged hospitalisation. Our objective was to characterize SARS-CoV-2 related AP and study the impact of SARS-CoV-2 superinfection on outcomes in AP.
Methods: In this multicentre prospective study, all patients with AP and SARS-CoV-2 infection between August 2020 and February 2021 were divided into two groups: SARS-CoV-2-related AP and superadded SARS-CoV-2 infection in patients with AP. The two groups were compared with each other and the whole cohort was compared with a non-COVID AP cohort.
Results: A total of 85 patients with SARS-CoV-2 and AP (SARS-CoV-2-related AP; n = 18 and AP with SARS-CoV-2 superadded infection; n = 67) were included during the study period. They had a higher mortality [28 (32.9%) vs. 44 (19.1%), aOR 2.8 (95% CI, 1.5-5.3)] than 230 propensity matched non-COVID AP patients. Mortality in SARS-CoV-2 and AP patients was due to critical COVID. SARS-CoV-2-related- AP (n = 18) had a higher but statistically insignificant mortality than SARS-CoV-2 superinfection in AP [8/18 (44.4%) vs 20/67 (29.8%), p = 0.24]. On multivariable analysis, infection with SARS-CoV-2 (aHR 2.3; 95% CI, 1.43.7) was a predictor of in-hospital mortality in addition to organ failure (OF) in patients with AP.
Conclusion: Patients with AP and SARS-CoV-2 infection had a higher mortality than matched non-COVID AP patients which was largely attributable to the severity of COVID-19. SARS-CoV-2 related AP had higher OF and in-hospital mortality.
Keywords: Acute pancreatitis; COVID-19; Coronavirus; Organ failure; SARS-CoV-2; Virus induced pancreatitis.
. 2022 Jan 25;S1424-3903(22)00009-6.
doi: 10.1016/j.pan.2022.01.008. Online ahead of print.
Virus related acute pancreatitis and virus superinfection in the 'Dual disease' model of acute pancreatitis and SARS-Co-V2 infection: A multicentre prospective study
Jayanta Samanta[SUP] 1 [/SUP], Soumya Jagannath Mahapatra[SUP] 2 [/SUP], Naveen Kumar[SUP] 1 [/SUP], Anshuman Elhence[SUP] 2 [/SUP], Jahnvi Dhar[SUP] 1 [/SUP], Anany Gupta[SUP] 2 [/SUP], Anugrah Dhooria[SUP] 2 [/SUP], Ashish Bhalla[SUP] 3 [/SUP], Manya Prasad[SUP] 4 [/SUP], Aritra Das[SUP] 5 [/SUP], Raju Sharma[SUP] 6 [/SUP], Rakesh Kochhar[SUP] 7 [/SUP], Pramod K Garg[SUP] 8 [/SUP], GAIN Study group
Collaborators, Affiliations
- PMID: 35131169
- DOI: 10.1016/j.pan.2022.01.008
Abstract
Background: SARS-CoV-2 can cause acute pancreatitis (AP) and SARS-CoV-2 superinfection can occur in patients with AP during prolonged hospitalisation. Our objective was to characterize SARS-CoV-2 related AP and study the impact of SARS-CoV-2 superinfection on outcomes in AP.
Methods: In this multicentre prospective study, all patients with AP and SARS-CoV-2 infection between August 2020 and February 2021 were divided into two groups: SARS-CoV-2-related AP and superadded SARS-CoV-2 infection in patients with AP. The two groups were compared with each other and the whole cohort was compared with a non-COVID AP cohort.
Results: A total of 85 patients with SARS-CoV-2 and AP (SARS-CoV-2-related AP; n = 18 and AP with SARS-CoV-2 superadded infection; n = 67) were included during the study period. They had a higher mortality [28 (32.9%) vs. 44 (19.1%), aOR 2.8 (95% CI, 1.5-5.3)] than 230 propensity matched non-COVID AP patients. Mortality in SARS-CoV-2 and AP patients was due to critical COVID. SARS-CoV-2-related- AP (n = 18) had a higher but statistically insignificant mortality than SARS-CoV-2 superinfection in AP [8/18 (44.4%) vs 20/67 (29.8%), p = 0.24]. On multivariable analysis, infection with SARS-CoV-2 (aHR 2.3; 95% CI, 1.43.7) was a predictor of in-hospital mortality in addition to organ failure (OF) in patients with AP.
Conclusion: Patients with AP and SARS-CoV-2 infection had a higher mortality than matched non-COVID AP patients which was largely attributable to the severity of COVID-19. SARS-CoV-2 related AP had higher OF and in-hospital mortality.
Keywords: Acute pancreatitis; COVID-19; Coronavirus; Organ failure; SARS-CoV-2; Virus induced pancreatitis.