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PAHO rejects report of resistant H1N1 cases on US-Mexico border

Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

Snicklefritz said:
Does this imply that CDC does not trust local officials to report 'accurately'?
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This means that the CDC has NO real mechanism to monitor schools, which they admitted last year when I asked about school outbreaks during a conference call on Tamiflu resistance.
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

Snicklefritz said:
Like I said before:
Click to expand...
>>MSNBC is reporting that six people have the virus that is resistant to Tamiflu just 220 miles away from San Antonio in McAllen, as well as other border towns like El Paso.<<
I suspect someone let the cat out of the bag a bit early.
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

Well, now that the MSM has the story, the whole thing may really spin up. If we're going to have panic, it should be based on solid information.

"To everything there is a season,
and I time for every purpose under heaven."

Joni Mitchell - ha, ha!
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

Snicklefritz said:
Well, now that the MSM has the story, the whole thing may really spin up. If we're going to have panic, it should be based on solid information.

"To everything there is a season,
and I time for every purpose under heaven."

Joni Mitchell - ha, ha!
Click to expand...
Usually when they use a number like 6 cases, it is more significant that "a few", and now that the cat is out of the bag, real numbers will start to appear.
The 0.5% resisatnce that Roche keeps spitting out is PURE media myth and has NOTHING to do with pandemic H1N1.
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

niman said:
..........The 0.5% resisatnce that Roche keeps spitting out is PURE media myth and has NOTHING to do with pandemic H1N1.
Click to expand...

Is that the same number they pulled out when resistant H5N1 1st showed up in Egypt?

.
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

AlaskaDenise said:
Is that the same number they pulled out when resistant H5N1 1st showed up in Egypt?

.
Click to expand...
The number is based on resistance years ago (primarily in H3N2) in children in Japan who were given sub-optimal levels of Tamiflu. The number of recent (since 2006) H3N2 sequences with Tamiflu resistance is ZERO and the vast majority of H1N1 cases with H274Y were NOT treated with Tamiflu.
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

I think the title change for this thread is misleading. It is likely that PAHO is trying to "pull back" the story by splitting hairs and taking a position that the detection of H274Y is only "diagnostic" and the samples have not been formally tested for resistance, which is just an excuse to delay/withhold the information on the multiple cases of Tamiflu resistance that have been found, as indiacted in the original title.
 
Re: Tamiflu-resistant swine flu found on US-Mexico border

Re: Tamiflu-resistant swine flu found on US-Mexico border

niman said:
PAHO rejects report of resistant H1N1 cases on US-Mexico border


Cerqueira said she repeated several times that she had no information on any antiviral-resistant cases in the border area. "It is an unfortunate misinterpretation that needs to be clarified," she wrote.

She wrote that she has heard about two antiviral-resistant cases from a physician in Colombia, but that the source did not say they were near the US-Mexico border.


http://www.cidrap.umn.edu/cidrap/content/influenza/swineflu/news/aug0409resistance.html
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These comments are still not adding up. There are confirmed H1N1 cases at multiple locations along the Texas / Mexico border, including deaths at multiple locations (see map)

http://flutracker.rhizalabs.com/flu/gmap0908041002.html?lat=27.839076094777816&lon=-105.46875&zoom=6

and cross traffic with Mexico would include Arizona and California, where there are also multiple locations with confirmed cases and deaths on both sides of tborder, so the singling out of two locations in Texas of areas of increased concnern, without reports of Tamiflu resistance, makes little sense. Moreover, the description of the two cases specifically mentions diagnositic resistance, and the presence of H274Y is frequently considered diagnostic for resistance when samples are not formally tested for resistance. At Genbank, sequences with H274Y are labeled with and astrisk with the following warning

* This sequence has the H274Y mutation that might confer resistance to Oseltamivir.

Since it is well known that N1 with H274Y confers resistance in the range of 300-1000 (takes 300 to 1000X the amount of Tamiflu to acheive the same level of inhibition seen in wild type), the presence of H274Y is considered "diagnostic" of resistance (which is confirmed when such samples are directly tested with multiple concentrations of Tamiflu).

Thus, the confusion may simply be PAHO clinging to the absence of formal testing as an excuse for stating there is "no data" on resistance becasue there has been no direct resistance testing (which is only done at a handful of locations world wide - the Tamiflu resistance in Egypt, indicated by another polymorphisms linked to resistance, S294N, was "confirmed" in Atlanta by the CDC, which showed that the S294N confered the same resistance (10-20 fold) previously reported for this genetic change in other isolates.

The subsequent reports of 6 cases of resistance suggest the original remarks of resistance on the Texas / Mexico story were accurate, current "rejection reports" notwithstanding.
 
Re: Tamiflu-resistant swine flu found on US-Mexico border

Re: Tamiflu-resistant swine flu found on US-Mexico border

niman said:
PAHO rejects report of resistant H1N1 cases on US-Mexico border

Lisa Schnirring * Staff Writer


Cerqueira said she repeated several times that she had no information on any antiviral-resistant cases in the border area. "It is an unfortunate misinterpretation that needs to be clarified," she wrote.

http://www.cidrap.umn.edu/cidrap/content/influenza/swineflu/news/aug0409resistance.html
Click to expand...
"No information ON any antiviral cases" can simply indicate a lack of clinical details (i.e. if and when patients were treated with Tamiflu) which is distinct from "no information OF any antiviral case".
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

niman said:
I think the title change for this thread is misleading. It is likely that PAHO is trying to "pull back" the story by splitting hairs and taking a position that the detection of H274Y is only "diagnostic" and the samples have not been formally tested for resistance, which is just an excuse to delay/withhold the information on the multiple cases of Tamiflu resistance that have been found, as indiacted in the original title.
Click to expand...

Agreed. The way in which this was retracted doesn't quite pass the smell test to me. Conflicting reports, perhaps?
 
Re: PAHO rejects report of resistant H1N1 cases on US-Mexico border

No Tamiflu Resistant Swine Flu Cases On Mexico/US Border -WHO

ZURICH -(Dow Jones)- The World Health Organization hasn't observed any cases of resistance against the swine flu antiviral drug Tamiflu along the U.S./ Mexican border, WHO spokeswoman Aphaluck Bhatiasevi said Wednesday.

The remarks are in response to a press report quoting WHO Chief Medical Officer Maria Teresa Cerqueira as saying WHO had observed cases of the A/H1N1 swine flu virus along the border between the U.S. and Mexico that have shown a resistance to Roche Holding AG's (ROG.VX) antiviral drug Tamiflu.

"The chief medical officer was misquoted," said Bhatiasevi. "She had said that there are cases of the H1N1/A virus along the border and that the WHO recommends surveying those cases in case a potential resistance occurs. But currently there are no cases of resistance along the border," Bhatiasevi said.

She added that a total of six cases in four countries have shown a resistance to Tamiflu, but that that's a "small number of isolated cases."

The countries are Denmark, Hong Kong, Japan and Canada, according to information on the WHO's web site.

Organization Web site: www.who.int

-By Julia Mengewein, Dow Jones Newswires

http://www.nasdaq.com/aspx/stock-ma...istant-swine-flu-cases-on-mexico/us-borderwho
 
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