tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 May 7;9(7)
fac227.
doi: 10.1093/ofid/ofac227. eCollection 2022 Jul.
Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection
Christian Gaebler[SUP] 1 [/SUP], Justin DaSilva[SUP] 2 [/SUP], Eva Bednarski[SUP] 2 [/SUP], Frauke Muecksch[SUP] 2 [/SUP], Fabian Schmidt[SUP] 2 [/SUP], Yiska Weisblum[SUP] 2 [/SUP], Katrina G Millard[SUP] 1 [/SUP], Martina Turroja[SUP] 1 [/SUP], Alice Cho[SUP] 1 [/SUP], Zijun Wang[SUP] 1 [/SUP], Marina Caskey[SUP] 1 [/SUP], Michel C Nussenzweig[SUP] 1 [/SUP], Paul D Bieniasz[SUP] 2 [/SUP], Theodora Hatziioannou[SUP] 2 [/SUP]
Affiliations
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.
Keywords: Omicron; SARS-CoV-2; breakthrough infection; neutralization; vaccination.
. 2022 May 7;9(7)
fac227.doi: 10.1093/ofid/ofac227. eCollection 2022 Jul.
Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection
Christian Gaebler[SUP] 1 [/SUP], Justin DaSilva[SUP] 2 [/SUP], Eva Bednarski[SUP] 2 [/SUP], Frauke Muecksch[SUP] 2 [/SUP], Fabian Schmidt[SUP] 2 [/SUP], Yiska Weisblum[SUP] 2 [/SUP], Katrina G Millard[SUP] 1 [/SUP], Martina Turroja[SUP] 1 [/SUP], Alice Cho[SUP] 1 [/SUP], Zijun Wang[SUP] 1 [/SUP], Marina Caskey[SUP] 1 [/SUP], Michel C Nussenzweig[SUP] 1 [/SUP], Paul D Bieniasz[SUP] 2 [/SUP], Theodora Hatziioannou[SUP] 2 [/SUP]
Affiliations
- PMID: 35818364
- PMCID: PMC9129198
- DOI: 10.1093/ofid/ofac227
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.
Keywords: Omicron; SARS-CoV-2; breakthrough infection; neutralization; vaccination.