tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Oct 5;10(11)
fad493.
doi: 10.1093/ofid/ofad493. eCollection 2023 Nov. Risk of New-Onset Long COVID Following Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2: A Community-Based Cohort Study
Matthew L Bosworth[SUP] 1 [/SUP], Boran Shenhuy[SUP] 2 [/SUP], A Sarah Walker[SUP] 3 4 [/SUP], Vahé Nafilyan[SUP] 1 5 [/SUP], Nisreen A Alwan[SUP] 6 7 [/SUP], Margaret E O'Hara[SUP] 8 [/SUP], Daniel Ayoubkhani[SUP] 1 9 [/SUP]
Affiliations
Background: Little is known about the risk of long COVID following reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We estimated the likelihood of new-onset, self-reported long COVID after a second SARS-CoV-2 infection, compared to a first infection.
Methods: We included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported long COVID 12-20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset long COVID using logistic regression, comparing second to first infections, controlling for sociodemographic characteristics and calendar date of infection, plus vaccination status in participants ≥16 years of age.
Results: Overall, long COVID was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those aged <16 years were 1.0% and 0.6%. The aOR for long COVID after second compared to first infections was 0.72 (95% confidence interval [CI], .63-.81) for those ≥16 years and 0.93 (95% CI, .57-1.53) for those <16 years.
Conclusions: The risk of new-onset long COVID after a second SARS-CoV-2 infection is lower than that after a first infection for persons aged ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset long COVID after a second infection, with around 1 in 40 of those aged ≥16 years and 1 in 165 of those <16 years reporting long COVID after a second infection.
Keywords: COVID-19; coronavirus; long COVID; post-COVID condition; reinfection.
. 2023 Oct 5;10(11)
fad493.doi: 10.1093/ofid/ofad493. eCollection 2023 Nov. Risk of New-Onset Long COVID Following Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2: A Community-Based Cohort Study
Matthew L Bosworth[SUP] 1 [/SUP], Boran Shenhuy[SUP] 2 [/SUP], A Sarah Walker[SUP] 3 4 [/SUP], Vahé Nafilyan[SUP] 1 5 [/SUP], Nisreen A Alwan[SUP] 6 7 [/SUP], Margaret E O'Hara[SUP] 8 [/SUP], Daniel Ayoubkhani[SUP] 1 9 [/SUP]
Affiliations
- PMID: 37953820
- PMCID: PMC10633780
- DOI: 10.1093/ofid/ofad493
Background: Little is known about the risk of long COVID following reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We estimated the likelihood of new-onset, self-reported long COVID after a second SARS-CoV-2 infection, compared to a first infection.
Methods: We included UK COVID-19 Infection Survey participants who tested positive for SARS-CoV-2 between 1 November 2021 and 8 October 2022. The primary outcome was self-reported long COVID 12-20 weeks after each infection. Separate analyses were performed for those <16 years and ≥16 years. We estimated adjusted odds ratios (aORs) for new-onset long COVID using logistic regression, comparing second to first infections, controlling for sociodemographic characteristics and calendar date of infection, plus vaccination status in participants ≥16 years of age.
Results: Overall, long COVID was reported by those ≥16 years after 4.0% and 2.4% of first and second infections, respectively; the corresponding estimates among those aged <16 years were 1.0% and 0.6%. The aOR for long COVID after second compared to first infections was 0.72 (95% confidence interval [CI], .63-.81) for those ≥16 years and 0.93 (95% CI, .57-1.53) for those <16 years.
Conclusions: The risk of new-onset long COVID after a second SARS-CoV-2 infection is lower than that after a first infection for persons aged ≥16 years, though there is no evidence of a difference in risk for those <16 years. However, there remains some risk of new-onset long COVID after a second infection, with around 1 in 40 of those aged ≥16 years and 1 in 165 of those <16 years reporting long COVID after a second infection.
Keywords: COVID-19; coronavirus; long COVID; post-COVID condition; reinfection.