Open Forum Infect Dis . Examination of Common Coronavirus Antibodies in SARS-CoV-2-Infected and Uninfected Participants in a Household Transmission

[tetano]

Open Forum Infect Dis


. 2022 Jul 20;9(7)fac212.
doi: 10.1093/ofid/ofac212. eCollection 2022 Jul.
Examination of Common Coronavirus Antibodies in SARS-CoV-2-Infected and Uninfected Participants in a Household Transmission Investigation


Megan M Stumpf[SUP] 1 [/SUP], Brandi Freeman[SUP] 1 [/SUP], Lisa Mills[SUP] 1 [/SUP], Sandra Lester[SUP] 1 [/SUP], Victoria T Chu[SUP] 1 [/SUP], Hannah L Kirking[SUP] 1 [/SUP], Natalie J Thornburg[SUP] 1 [/SUP], Marie E Killerby[SUP] 1 [/SUP]



Affiliations

• PMID: 35873297
• PMCID: PMC9297157
• DOI: 10.1093/ofid/ofac212

Abstract

We compared paired serum specimens from household contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases with detectable SARS-CoV-2 seroconversion with contacts who remained seronegative. No protection from SARS-CoV-2 infection was associated with human coronavirus antibodies; however, an increase in common betacoronavirus antibodies was associated with seroconversion to SARS-CoV-2 in mild to moderately ill cases.

Keywords: COVID-19; SARS-CoV-2; common coronaviruses; human coronaviruses; immunology.