Open Forum Infect Dis . Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Imm

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Open Forum Infect Dis


. 2022 Oct 17;9(11)fac544.
doi: 10.1093/ofid/ofac544. eCollection 2022 Nov.
Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers


M Ali Rai[SUP] 1 [/SUP], Victoria Shi[SUP] 1 [/SUP], Brooke D Kennedy[SUP] 1 [/SUP], Jesse S Justement[SUP] 1 [/SUP], Kathleen Gittens[SUP] 2 [/SUP], Genevieve McCormack[SUP] 1 [/SUP], Jana Blazkova[SUP] 1 [/SUP], Susan Moir[SUP] 1 [/SUP], Tae-Wook Chun[SUP] 1 [/SUP]



Affiliations

• PMID: 36345429
• PMCID: PMC9619736
• DOI: 10.1093/ofid/ofac544

Abstract

We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication.

Keywords: HIV; HIV reservoirs; SARS-CoV-2; booster vaccine; immune markers and responses.