tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2020 Jul 5;7(7)
faa283.
doi: 10.1093/ofid/ofaa283. eCollection 2020 Jul.
Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Shuang Xu[SUP] 1 [/SUP], Fei Shao[SUP] 2 3 [/SUP], Banghe Bao[SUP] 4 [/SUP], Xuedi Ma[SUP] 5 [/SUP], Zhouming Xu[SUP] 5 6 [/SUP], Jiwen You[SUP] 5 [/SUP], Peng Zhao[SUP] 5 [/SUP], Yuwei Liu[SUP] 5 [/SUP], Michael Ng[SUP] 6 [/SUP], Hao Cui[SUP] 3 [/SUP], Changxiao Yu[SUP] 3 [/SUP], Qing Zhang[SUP] 7 [/SUP], Dandan Li[SUP] 8 [/SUP], Ziren Tang[SUP] 2 3 [/SUP], Peng Sun[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China.
Methods: We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1.
Results: Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8-9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1.
Conclusions: Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.
Keywords: COVID-19; H1N1; neonatal; pregnancy; vertical transmission.
. 2020 Jul 5;7(7)
faa283.doi: 10.1093/ofid/ofaa283. eCollection 2020 Jul.
Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Shuang Xu[SUP] 1 [/SUP], Fei Shao[SUP] 2 3 [/SUP], Banghe Bao[SUP] 4 [/SUP], Xuedi Ma[SUP] 5 [/SUP], Zhouming Xu[SUP] 5 6 [/SUP], Jiwen You[SUP] 5 [/SUP], Peng Zhao[SUP] 5 [/SUP], Yuwei Liu[SUP] 5 [/SUP], Michael Ng[SUP] 6 [/SUP], Hao Cui[SUP] 3 [/SUP], Changxiao Yu[SUP] 3 [/SUP], Qing Zhang[SUP] 7 [/SUP], Dandan Li[SUP] 8 [/SUP], Ziren Tang[SUP] 2 3 [/SUP], Peng Sun[SUP] 1 [/SUP]
Affiliations
- PMID: 32743014
- PMCID: PMC7384380
- DOI: 10.1093/ofid/ofaa283
Abstract
Background: Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China.
Methods: We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1.
Results: Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8-9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1.
Conclusions: Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.
Keywords: COVID-19; H1N1; neonatal; pregnancy; vertical transmission.