Open Forum Infect Dis . Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Pediatric Patient

[tetano]

Open Forum Infect Dis


. 2026 May 7;13(5)fag283.
doi: 10.1093/ofid/ofag283. eCollection 2026 May.
Central Nervous System Involvement by Novel Clade 2.3.2.1e H5N1 Avian Influenza Virus in a Pediatric Patient

Phung Nguyen The Nguyen[SUP] 1 2 [/SUP], Nguyen Thanh Hung[SUP] 2 [/SUP], Ngo Ngoc Quang Minh[SUP] 2 [/SUP], Nguyen Thi Thu Hong[SUP] 3 [/SUP], Nguyen Thi Thanh Huong[SUP] 2 [/SUP], Cao Minh Hiep[SUP] 2 [/SUP], Le Nguyen Thanh Nhan[SUP] 2 [/SUP], Tran Van Dinh[SUP] 2 [/SUP], Du Tuan Quy[SUP] 2 [/SUP], Tran Thanh Thuc[SUP] 1 2 [/SUP], Tran Minh Nhut[SUP] 2 [/SUP], Nguyen Thi Han Ny[SUP] 3 [/SUP], Lam Anh Nguyet[SUP] 1 3 [/SUP], Le Nguyen Truc Nhu[SUP] 3 [/SUP], Do Duong Kim Han[SUP] 3 [/SUP], Truong Hoang Chau Truc[SUP] 3 [/SUP], Le Thi Tam Uyen[SUP] 4 [/SUP], Nghiem My Ngoc[SUP] 4 [/SUP], Tran Nguyen Phuong Thao[SUP] 4 [/SUP], Tran Thi Thanh Tam[SUP] 4 [/SUP], Sandy Tze-Minn Mak[SUP] 5 [/SUP], Jurre Y Siegers[SUP] 6 [/SUP], Sebastian Maurer-Stroh[SUP] 5 7 [/SUP], Nguyen Thanh Dung[SUP] 5 [/SUP], Erik A Karlsson[SUP] 6 [/SUP], Guy Thwaites[SUP] 3 8 [/SUP], Chee Wah Tan[SUP] 9 [/SUP], Nguyen Van Vinh Chau[SUP] 10 [/SUP], Le Van Tan[SUP] 3 8 [/SUP]; SEACOVARIANTS and H5N1 Consortia


Collaborators, Affiliations

• PMID: 42182835
• PMCID: PMC13197838
• DOI: 10.1093/ofid/ofag283

Abstract

Novel clade 2.3.2.1e A(H5N1) virus was detected in cerebrospinal fluid but not in respiratory, rectal swab, or blood samples of an 8-year-old boy presenting with meningoencephalitis without respiratory symptoms. Cerebrospinal fluid A(H5N1) hemagglutinin-specific antibody levels were higher than those of sera. Clinicians should be aware of emerging clade 2.3.2.1e A(H5N1)-associated meningoencephalitis.

Keywords: H5N1; Vietnam; highly pathogenic avian influenza; meningoecephalitis.

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