tetano
Editor, Senior Moderator
Open Biol
. 2021 Jan;11(1):200347.
doi: 10.1098/rsob.200347. Epub 2021 Jan 20.
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
Shubhadeep Roychoudhury[SUP] 1 [/SUP], Anandan Das[SUP] 1 [/SUP], Niraj Kumar Jha[SUP] 2 [/SUP], Kavindra Kumar Kesari[SUP] 3 [/SUP], Shatabhisha Roychoudhury[SUP] 4 5 [/SUP], Saurabh Kumar Jha[SUP] 2 [/SUP], Raghavender Kosgi[SUP] 6 [/SUP], Arun Paul Choudhury[SUP] 7 [/SUP], Norbert Lukac[SUP] 8 [/SUP], Nithar Ranjan Madhu[SUP] 9 [/SUP], Dhruv Kumar[SUP] 10 [/SUP], Petr Slama[SUP] 11 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.
Keywords: ACE2; COVID-19; SARS-CoV-2 infection; fertility; male reproduction; testicular damage.
. 2021 Jan;11(1):200347.
doi: 10.1098/rsob.200347. Epub 2021 Jan 20.
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
Shubhadeep Roychoudhury[SUP] 1 [/SUP], Anandan Das[SUP] 1 [/SUP], Niraj Kumar Jha[SUP] 2 [/SUP], Kavindra Kumar Kesari[SUP] 3 [/SUP], Shatabhisha Roychoudhury[SUP] 4 5 [/SUP], Saurabh Kumar Jha[SUP] 2 [/SUP], Raghavender Kosgi[SUP] 6 [/SUP], Arun Paul Choudhury[SUP] 7 [/SUP], Norbert Lukac[SUP] 8 [/SUP], Nithar Ranjan Madhu[SUP] 9 [/SUP], Dhruv Kumar[SUP] 10 [/SUP], Petr Slama[SUP] 11 [/SUP]
Affiliations
- PMID: 33465325
- DOI: 10.1098/rsob.200347
Abstract
Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.
Keywords: ACE2; COVID-19; SARS-CoV-2 infection; fertility; male reproduction; testicular damage.