tetano
Editor, Senior Moderator
Obesity (Silver Spring). 2020 Apr 23. doi: 10.1002/oby.22849. [Epub ahead of print]
Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2?
Zbinden-Foncea H[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Francaux M[SUP]3[/SUP], Deldicque L[SUP]3[/SUP], Hawley JA[SUP]4[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China in late 2019 and has since spread rapidly to every continent in the world. This pandemic continues to cause widespread personal suffering, along with severe pressure on medical and health care providers. The symtoms of SARS-CoV-2 and the subsequent prognosis is worsened in individuals who have pre-exisiting comorbidities prior to infection by the virus. Individuals with obesity/overweight, insulin resistance and diabetes typically have chronic low-grade inflammation characterized by increased levels of several pro-inflammatory cytokines and the inflammasome: this state predisposes to greater risk for infection along with more adverse outcomes. Here we consider whether a high level of cardiorespiratory fitness induced by prior exercise training may confer some innate immune-protection against Covid-19 by attenuating the "cytokine storm syndrome" often experienced by "at risk" individuals.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; Obesity; exercise; immune system; insulin resistance
PMID:32324968DOI:10.1002/oby.22849
Does high cardiorespiratory fitness confer some protection against pro-inflammatory responses after infection by SARS-CoV-2?
Zbinden-Foncea H[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Francaux M[SUP]3[/SUP], Deldicque L[SUP]3[/SUP], Hawley JA[SUP]4[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in China in late 2019 and has since spread rapidly to every continent in the world. This pandemic continues to cause widespread personal suffering, along with severe pressure on medical and health care providers. The symtoms of SARS-CoV-2 and the subsequent prognosis is worsened in individuals who have pre-exisiting comorbidities prior to infection by the virus. Individuals with obesity/overweight, insulin resistance and diabetes typically have chronic low-grade inflammation characterized by increased levels of several pro-inflammatory cytokines and the inflammasome: this state predisposes to greater risk for infection along with more adverse outcomes. Here we consider whether a high level of cardiorespiratory fitness induced by prior exercise training may confer some innate immune-protection against Covid-19 by attenuating the "cytokine storm syndrome" often experienced by "at risk" individuals.
This article is protected by copyright. All rights reserved.
KEYWORDS:
COVID-19; Obesity; exercise; immune system; insulin resistance
PMID:32324968DOI:10.1002/oby.22849