tetano
Editor, Senior Moderator
Viruses. 2013 Jul 18;5(7):1824-49. doi: 10.3390/v5071824.
Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.
Kuss SK, Mata MA, Zhang L, Fontoura BM.
Source
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Sharon.Kuss@utsouthwestern.edu.
Abstract
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
PMID:
23872491
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23872491
Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.
Kuss SK, Mata MA, Zhang L, Fontoura BM.
Source
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Sharon.Kuss@utsouthwestern.edu.
Abstract
Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.
PMID:
23872491
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/23872491