tetano
Editor, Senior Moderator
NPJ Vaccines
. 2025 Aug 19;10(1):197.
doi: 10.1038/s41541-025-01238-2. Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
Nir Paran[SUP] 1 2 [/SUP], Christoph Wirblich[SUP] 1 [/SUP], Catherine Olal[SUP] 3 4 [/SUP], Alessandro Tarquinio[SUP] 1 [/SUP], Kimberly H Lohmeyer[SUP] 5 [/SUP], Drishya Kurup[SUP] 1 2 [/SUP], Stacey Schultz-Cherry[SUP] 6 [/SUP], Ismaila Shittu[SUP] 7 [/SUP], Gregory C Gray[SUP] 3 4 7 [/SUP], Dennis A Bente[SUP] 3 4 [/SUP], Pia U Olafson[SUP] 5 [/SUP], Matthias J Schnell[SUP] 8 9 [/SUP]
Affiliations
The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.
. 2025 Aug 19;10(1):197.
doi: 10.1038/s41541-025-01238-2. Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle
Nir Paran[SUP] 1 2 [/SUP], Christoph Wirblich[SUP] 1 [/SUP], Catherine Olal[SUP] 3 4 [/SUP], Alessandro Tarquinio[SUP] 1 [/SUP], Kimberly H Lohmeyer[SUP] 5 [/SUP], Drishya Kurup[SUP] 1 2 [/SUP], Stacey Schultz-Cherry[SUP] 6 [/SUP], Ismaila Shittu[SUP] 7 [/SUP], Gregory C Gray[SUP] 3 4 7 [/SUP], Dennis A Bente[SUP] 3 4 [/SUP], Pia U Olafson[SUP] 5 [/SUP], Matthias J Schnell[SUP] 8 9 [/SUP]
Affiliations
- PMID: 40830096
- DOI: 10.1038/s41541-025-01238-2
The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.