NPJ Vaccines . An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

[tetano]

NPJ Vaccines


. 2024 Oct 14;9(1):189.
doi: 10.1038/s41541-024-00988-9. An mRNA vaccine candidate encoding H5HA clade 2.3.4.4b protects mice from clade 2.3.2.1a virus infection

Shiho Chiba[SUP] 1 2 3 [/SUP], Maki Kiso[SUP] 1 3 [/SUP], Shinya Yamada[SUP] 4 [/SUP], Kazuhiko Someya[SUP] 4 [/SUP], Yoshikuni Onodera[SUP] 4 [/SUP], Aya Yamaguchi[SUP] 4 [/SUP], Satoko Matsunaga[SUP] 4 [/SUP], Ryuta Uraki[SUP] 1 3 5 [/SUP], Kiyoko Iwatsuki-Horimoto[SUP] 1 3 [/SUP], Seiya Yamayoshi[SUP] 1 3 5 [/SUP], Fumihiko Takeshita[SUP] 4 [/SUP], Yoshihiro Kawaoka[SUP] 6 7 8 9 [/SUP]



Affiliations

• PMID: 39402112
• DOI: 10.1038/s41541-024-00988-9

Abstract

Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-base


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