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Source: https://wwwnc.cdc.gov/eid/article/26/12/20-0272_article
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 26, Number 12—December 2020
Novel Rickettsia Species Infecting Dogs, United States
James M. Wilson, Edward B. Breitschwerdt, Nicholas B. Juhasz, Henry S. Marr, Joao Felipe de Brito Galv?o, Carmela L. Pratt, and Barbara A. QurolloComments to Author
Author affiliations: North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA (J.M. Wilson, E.B. Breitschwerdt, N.B. Juhasz, H.S. Marr, B.A. Qurollo); VCA Arboretum View Animal Hospital, Downers Grove, Illinois, USA (J.F. de Brito Galv?o); Oklahoma Veterinary Specialists, Tulsa Oklahoma, USA (C.L. Pratt)
Abstract
In 2018 and 2019, spotted fever was suspected in 3 dogs in 3 US states. The dogs had fever and hematological abnormalities; blood samples were Rickettsia seroreactive. Identical Rickettsia DNA sequences were amplified from the samples. Multilocus phylogenetic analysis showed the dogs were infected with a novel Rickettsia species related to human Rickettsia pathogens.
In the United States, tickborne Rickettsia parkeri, R. philipii (Rickettsia 364D), and R. rickettsii, causative agents of Rocky Mountain spotted fever (RMSF), are well-documented human spotted fever group (SFG) rickettsioses (1). R. rickettsii is the only known cause of SFG rickettsioses in dogs (2). The extent to which other SFG Rickettsia are pathogenic in dogs is unclear; however, SFG Rickettsia seroprevalence is high among dogs in the United States and Mexico (3,4). The increased R. rickettsii seroprevalence in humans in the United States during the past decade has been attributed to SFG Rickettsia cross-reactivity (1,5).
We report 3 dogs with febrile illness located in different US states. Samples from the dogs were R. rickettsii seroreactive. Identical Rickettsia DNA gene sequences were obtained from each dog’s blood specimen and used to investigate Rickettsia spp....
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 26, Number 12—December 2020
Novel Rickettsia Species Infecting Dogs, United States
James M. Wilson, Edward B. Breitschwerdt, Nicholas B. Juhasz, Henry S. Marr, Joao Felipe de Brito Galv?o, Carmela L. Pratt, and Barbara A. QurolloComments to Author
Author affiliations: North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA (J.M. Wilson, E.B. Breitschwerdt, N.B. Juhasz, H.S. Marr, B.A. Qurollo); VCA Arboretum View Animal Hospital, Downers Grove, Illinois, USA (J.F. de Brito Galv?o); Oklahoma Veterinary Specialists, Tulsa Oklahoma, USA (C.L. Pratt)
Abstract
In 2018 and 2019, spotted fever was suspected in 3 dogs in 3 US states. The dogs had fever and hematological abnormalities; blood samples were Rickettsia seroreactive. Identical Rickettsia DNA sequences were amplified from the samples. Multilocus phylogenetic analysis showed the dogs were infected with a novel Rickettsia species related to human Rickettsia pathogens.
In the United States, tickborne Rickettsia parkeri, R. philipii (Rickettsia 364D), and R. rickettsii, causative agents of Rocky Mountain spotted fever (RMSF), are well-documented human spotted fever group (SFG) rickettsioses (1). R. rickettsii is the only known cause of SFG rickettsioses in dogs (2). The extent to which other SFG Rickettsia are pathogenic in dogs is unclear; however, SFG Rickettsia seroprevalence is high among dogs in the United States and Mexico (3,4). The increased R. rickettsii seroprevalence in humans in the United States during the past decade has been attributed to SFG Rickettsia cross-reactivity (1,5).
We report 3 dogs with febrile illness located in different US states. Samples from the dogs were R. rickettsii seroreactive. Identical Rickettsia DNA gene sequences were obtained from each dog’s blood specimen and used to investigate Rickettsia spp....