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New Theory: h1n1 may be dud?

sbrooks

Well-known member
In Barry's book, The Great Influenza" he talks about "passage": The ability for a virus to increase lethality and become more effecient and virulent as it
passes through hosts. He uses an anthrax experiment on rabbits to illustrate his point (pages 176-78).

My question is, with the incredible spread of h1n1 (with modern day travel and increased population ) could the virus have already reached optimum
virulence and possibly recede and disappear as the US fall flu season develops?
 
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Re: New Theory: h1n1 may be dud?

This is what we all hope will happen. But no one knows. Anything can happen.
 
Re: New Theory: h1n1 may be dud?

Influenza is by nature unpredictable, so nobody can say with certainty.

Given that every human flu has had the PB2/627K mutation (that increases its ability to replicate at the temperature of humans), many are speculating that the odds are high this mutation will eventually be acquired.

I'm hoping that this new strain will have made one pass around the globe before that happens and we will all gain some protective immunity. :)

If this strain follows the historic patterns of other new strains, the one to disappear with be the prior seasonal strains (H3N2 and/or old H1N1).

.
 
Re: New Theory: h1n1 may be dud?

In Barry's book, The Great Influenza" he talks about "passage": The ability for a virus to increase lethality and become more effecient and virulent as it
passes through hosts. He uses an anthrax experiment on rabbits to illustrate his point (pages 176-78).

My question is, with the incredible spread of H1N1 (with modern day travel and increased population ) could the virus have already reached optimum
virulence and possibly recede and disappear as the US fall flu season develops?


I would tend to believe that with all the other variants out there to commingle with H1N1 is just the vehicle to H5, N7, H9 to humans.

Virulence will increase be it the second, third forth or so on.

We are at the beginning of a viral storm where novel strain created from factory farms and vaccines driving the virus to mutate.

6 Billion people and the differences of people, pigs and birds are commingling and becoming smaller.

We are at the start of a viral storm which will rise and fall for the next 5 years.

Better prep for the long haul. Nature is balancing back the conspiracies of man. Over population, resistant TB, MSRA, fresh water, carbon, the list goes on. The future doesn't look bright if you do not want to change the status quo. Accept change, weather the storm. Try to learn from afterward and begin anew.

That's my optomistic acessment. Want to hear my bad one? :)
 
Re: New Theory: h1n1 may be dud?

Corn: I'd love to see some links for your ideas, e.g., why would a "viral storm" last for 5 years?

Exactly what do you mean by "viral storm"?

.
 
Re: New Theory: h1n1 may be dud?

Sure Corn,
what is your worst case prediction?

I was teasing about that. Trying to add humor. Don't think it can get much worse when you factor in the ecomony and other global challenges that occur normally.
 
Re: New Theory: h1n1 may be dud?

Corn: I'd love to see some links for your ideas, e.g., why would a "viral storm" last for 5 years?

Exactly what do you mean by "viral storm"?

.

A viral storm to me would be what we have now. A novel strain H1N1 rises and falls only to be replaced by a new novel virus say H3, H5, H7 or H9 for example. So what we would have are echo's of two or possibly three novel strains bouncing around in the population at the same time or after the other. Kinda like ripples in a pond back and forth.

As far as the 5 year thing. I take the high end of the current pandemic estimates of 2-5 years that H1N1/09 will be waving around before herd immunity is developed.

The estimates were posted here and elsewhere a couple of months ago. I'll go quickly search for the link and thread but it might be till this eve to find it. I have to run out. Just doing a morning coffee breeze thru the headlines.

As you can tell I'm not too optimistic on humanities track record. We have opened up Pandora's Box many years ago and we have forestalled many man made tragedies, but it is all catching up with us. Look at all the resistance's developing everywhere. Our medicines for the common man are being the curve. It's payday and mother nature is writing the check.
 
Re: New Theory: h1n1 may be dud?

Corn: I'd love to see some links for your ideas, e.g., why would a "viral storm" last for 5 years?

Exactly what do you mean by "viral storm"?

.

Corn: Here's the two years quote, will have to dig some for the other article where the estimate says 2-5..... ( I think it was the mayo clinic?) But honestly, do you think we can have just one pandemic at a time from just one novel strain at a time?

The chances for more novel strains emerging as the current novel strain passes on humainzed characteristics while making round to infect half the planet are great as in the Canadian Hog workers, novel
H3N2 infections in Kansas and H5 endemic in at least 1/3 of the populated world.

The speed of developing Tamiflu resistance should also be an indicator as to how fast any emerging novel strains are moving to adapt.

Just as a guesser and common sense tell me, since this is just a discussion thread. I would look for Pan H1 to fire off some H5 or H3 soon. The experts say watch out for H9, H7.

Anyway, they just continue to bounce off each other. We never regian balance from the first novel strain or wave before the second strain or wave hits and so on......

Mix all that with MSRA, XTRTB, cdefectile? AIDS, SARS, some weird acting B and what's that other common virus that's freaking out? and a host of other emerging health threats and wala the "Storm" :)

I'm not a Bible thumper but the words that historically come to mind are, Biblical Proportions. Gotta go. See ya this eve....
----------------------------------------------------------
International

WHO DECLARES FLU PANDEMIC: COULD LAST TWO YEARS


Swine flu pandemic to last up to two years: WHO

The swine flu crisis has escalated into the world's first influenza pandemic in 40 years, the World Health Organization declared Thursday, after infecting tens of thousands of people in 74 countries.



WHO Director General Margaret Chan said the declaration of a "moderate" pandemic should not spark panic and did not mean the death toll from A(H1N1), which currently stands at 144, would rise sharply.



The UN body said it was not recommending the closure of borders nor restrictions in movement of people, goods and services. But it warned the virus was spreading beyond the Americas where it was first detected in April.



"We will be raising our pandemic alert level to level six; and this means that the world is moving into the early days of its first influenza pandemic in the 21st century," Chan told reporters after a meeting of scientific experts.



"At this time, the global assessment is that we are seeing a moderate pandemic," she added.



The WHO raised its six-phase alert level to five at the end of April, indicating an imminent pandemic.



The latest WHO figures show that the number of reported A(H1N1) infections has reached 28,774 in 74 countries, including 144 deaths.



The vast majority of the deaths have been in Mexico, the original epicentre of the outbreak, and no deaths have been announced outside the Americas.



"Moving to pandemic phase six level does not imply we will see increase in number of deaths or very severe cases," said Chan.



"Quite on the contrary, many people having mild disease will recover without medicine in some cases, and it is good news, but the tendency to move into complacency is our biggest concern," she added.



Chan said the health agency is concerned that the virus is causing "very severe disease disproportionately" among people 30 to 50 years old.



WHO Assistant Director General Keiji Fukuda warned the pandemic could last up to two years.



"For a period for one to two years the virus is going around the world, and is getting people infected in a way a pandemic virus will get people infected... We need to be flexible how we respond to it," said Fukuda.



The declaration comes amid growing evidence that the virus, which originated in Mexico two months ago, is now being widely transmitted between humans in Asia and Europe as well as the Americas.



EU officials promised measures on Thursday to reduce the impact of swine flu as Spain said 22 schools in the Madrid region had been hit by the virus.



The United States said it was well prepared to tackle the pandemic as it had been taking precautionary measures.



"We acted aggressively to stay ahead of the virus as it spread across the country. Now our challenge is to prepare for a possible return in the fall," Health Secretary Kathleen Sebelius said in a statement.



Hong Kong authorities Thursday ordered all primary schools in the city to be closed for two weeks after the first cluster of local swine flu cases was found in the Chinese territory.



In Germany, a school for Japanese youngsters in the western city of Duesseldorf was closed after 27 children tested positive for the virus. And in Australia, four swine flu victims were admitted to intensive care wards.



Following the announcement, the Red Cross and Red Crescent societies were mobilising to respond to the pandemic.



Chan said that it was up to individual countries to decide how to proceed given the outbreak was now classified as a pandemic.



"The global level assessment is very different from national level assessment because it has to take into account the vulnerability of the population in a specific country and also the health system resilience," she said.



Although no vaccine against A(H1N1) has yet to be produced, drug companies are looking to come up with one by the end of June or early July and last month sent three "seed viruses" to drug companies for use in making a vaccine.



Chan said the WHO would ask drug-makers to quickly prepare to produce swine flu vaccines once the production of seasonal flu shots ends in the next couple of weeks.



The last flu pandemic came after an outbreak of the H3N2 viral strain from 1968-69, which originated in Hong Kong, and went on to kill up to two million people.

Source: AFP


http://www.dostquangtri.gov.vn/English/EnglishDefault.asp?option=2&Menu=0&Sub=218&chitiet=2983
 
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