tetano
Editor, Senior Moderator
New Microbes New Infect
. 2020 Jul;36:100696.
doi: 10.1016/j.nmni.2020.100696. Epub 2020 May 20.
Severe Acute Respiratory Syndrome Coronavirus 2: Virus Mutations in Specific European Populations
F Copp?e[SUP] 1 [/SUP], J R Lechien[SUP] 2 [/SUP], A-E Decl?ves[SUP] 1 [/SUP], L Tafforeau[SUP] 3 [/SUP], S Saussez[SUP] 2 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is being intensively studied, particularly its evolution, in the increasingly available sequences between countries/continents with classical phylogenetic tree representation. More recently, certain protein mutations have been correlated with specific functional impacts. Our clinical data from patients suggest that clinical symptoms differ between European countries. Among other factors, SARS-CoV-2 mutations could explain these disparities. Our analyses point to an association of diverse mutations, including co-evolving ones, in a few SARS-CoV-2 proteins within specific countries. We therefore suggest combining clinical information from patients and the determination of the associated SARS-CoV-2 genome to better understand the specific symptoms.
Keywords: Amino acid replacements; G- S- and V-clades; co-evolved mutations; coronavirus disease 2019; european countries.
. 2020 Jul;36:100696.
doi: 10.1016/j.nmni.2020.100696. Epub 2020 May 20.
Severe Acute Respiratory Syndrome Coronavirus 2: Virus Mutations in Specific European Populations
F Copp?e[SUP] 1 [/SUP], J R Lechien[SUP] 2 [/SUP], A-E Decl?ves[SUP] 1 [/SUP], L Tafforeau[SUP] 3 [/SUP], S Saussez[SUP] 2 [/SUP]
Affiliations
- PMID: 32509310
- PMCID: PMC7238997
- DOI: 10.1016/j.nmni.2020.100696
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is being intensively studied, particularly its evolution, in the increasingly available sequences between countries/continents with classical phylogenetic tree representation. More recently, certain protein mutations have been correlated with specific functional impacts. Our clinical data from patients suggest that clinical symptoms differ between European countries. Among other factors, SARS-CoV-2 mutations could explain these disparities. Our analyses point to an association of diverse mutations, including co-evolving ones, in a few SARS-CoV-2 proteins within specific countries. We therefore suggest combining clinical information from patients and the determination of the associated SARS-CoV-2 genome to better understand the specific symptoms.
Keywords: Amino acid replacements; G- S- and V-clades; co-evolved mutations; coronavirus disease 2019; european countries.