tetano
Editor, Senior Moderator
Antiviral Res. 2019 Jul 16:104562. doi: 10.1016/j.antiviral.2019.104562. [Epub ahead of print]
[h=1]New antibody-based prevention and treatment options for influenza.[/h] Sedeyn K[SUP]1[/SUP], Saelens X[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The antigenic diversity of human influenza viruses represents a challenge to the development of vaccines with durable immune protection. In addition, small molecule anti-influenza viral drugs can bring clinical relief to influenza patients but the emergence of drug resistant viruses can rapidly limit the effectiveness of such drugs. In the past decade, a number of human monoclonal antibodies have been described that can bind to and neutralize a broad range of influenza A and B viruses. Most of these monoclonal antibodies are directed against the viral hemagglutinin (HA) stalk and some have now been evaluated in early to mid-stage clinical trials. An important conclusion from these clinical studies is that hemagglutinin stalk-specific antibodies are safe and can reduce influenza symptoms. In addition, examples of bi- and multi-specific anti-influenza antibodies are discussed, although such antibodies have not yet progressed into clinical testing. In the future, antibody-based therapies might become part of our arsenal to prevent and treat influenza.
Copyright ? 2019. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Antibody formatting; Broadly neutralizing; Clinical trial; Influenza; Monoclonal antibody
PMID: 31323236 DOI: 10.1016/j.antiviral.2019.104562
[h=1]New antibody-based prevention and treatment options for influenza.[/h] Sedeyn K[SUP]1[/SUP], Saelens X[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The antigenic diversity of human influenza viruses represents a challenge to the development of vaccines with durable immune protection. In addition, small molecule anti-influenza viral drugs can bring clinical relief to influenza patients but the emergence of drug resistant viruses can rapidly limit the effectiveness of such drugs. In the past decade, a number of human monoclonal antibodies have been described that can bind to and neutralize a broad range of influenza A and B viruses. Most of these monoclonal antibodies are directed against the viral hemagglutinin (HA) stalk and some have now been evaluated in early to mid-stage clinical trials. An important conclusion from these clinical studies is that hemagglutinin stalk-specific antibodies are safe and can reduce influenza symptoms. In addition, examples of bi- and multi-specific anti-influenza antibodies are discussed, although such antibodies have not yet progressed into clinical testing. In the future, antibody-based therapies might become part of our arsenal to prevent and treat influenza.
Copyright ? 2019. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Antibody formatting; Broadly neutralizing; Clinical trial; Influenza; Monoclonal antibody
PMID: 31323236 DOI: 10.1016/j.antiviral.2019.104562