tetano
Editor, Senior Moderator
Transfus Apher Sci. 2013 Nov 7. pii: S1473-0502(13)00327-3. doi: 10.1016/j.transci.2013.10.008. [Epub ahead of print]
Neutralization positive but apparent false-positive hepatitis B surface antigen in a blood donor following influenza vaccination.
Bigham M, Ponnampalam A.
Source
Canadian Blood Services, BC & Yukon Centre, Vancouver, British Columbia, Canada. Electronic address: mark.bigham@blood.ca.
Abstract
We report a case of transient, confirmed positive hepatitis B surface antigen (HBsAg) in a 25 year old long term Canadian Blood Services (CBS) donor, who reported receiving 2011-2012 seasonal trivalent (A/H1N1, A/H3N2, Influenza B) inactivated influenza vaccine two days before donation. To our knowledge, this report is the first published case implicating influenza vaccine as a possible factor in false-positive HBsAg test results. Seasonal incidence of repeat-reactive HBsAg among CBS donors suggests a potential contributory role of influenza vaccine or community acquired infection. We speculate that influenza vaccine may rarely be associated with sporadic, transient, false-positive HBsAg results.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
False-positive, HBsAg, Influenza, Vaccine
PMID:
24268563
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24268563
Neutralization positive but apparent false-positive hepatitis B surface antigen in a blood donor following influenza vaccination.
Bigham M, Ponnampalam A.
Source
Canadian Blood Services, BC & Yukon Centre, Vancouver, British Columbia, Canada. Electronic address: mark.bigham@blood.ca.
Abstract
We report a case of transient, confirmed positive hepatitis B surface antigen (HBsAg) in a 25 year old long term Canadian Blood Services (CBS) donor, who reported receiving 2011-2012 seasonal trivalent (A/H1N1, A/H3N2, Influenza B) inactivated influenza vaccine two days before donation. To our knowledge, this report is the first published case implicating influenza vaccine as a possible factor in false-positive HBsAg test results. Seasonal incidence of repeat-reactive HBsAg among CBS donors suggests a potential contributory role of influenza vaccine or community acquired infection. We speculate that influenza vaccine may rarely be associated with sporadic, transient, false-positive HBsAg results.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
False-positive, HBsAg, Influenza, Vaccine
PMID:
24268563
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24268563