tetano
Editor, Senior Moderator
Neurol Sci
. 2020 Jul 8.
doi: 10.1007/s10072-020-04541-z. Online ahead of print.
Neurological Diseases as Mortality Predictive Factors for Patients With COVID-19: A Retrospective Cohort Study
Jong-Moon Hwang[SUP] 1 2 [/SUP], Ju-Hyun Kim[SUP] 1 [/SUP], Jin-Sung Park[SUP] 3 [/SUP], Min Cheol Chang[SUP] 4 5 [/SUP], Donghwi Park[SUP] 6 [/SUP]
Affiliations
Abstract
Introduction: In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death.
Methods: In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients.
Results: In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age.
Conclusions: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.
Keywords: Alzheimer’s dementia; COVID-19; Chronic lung disease; Coronavirus.
. 2020 Jul 8.
doi: 10.1007/s10072-020-04541-z. Online ahead of print.
Neurological Diseases as Mortality Predictive Factors for Patients With COVID-19: A Retrospective Cohort Study
Jong-Moon Hwang[SUP] 1 2 [/SUP], Ju-Hyun Kim[SUP] 1 [/SUP], Jin-Sung Park[SUP] 3 [/SUP], Min Cheol Chang[SUP] 4 5 [/SUP], Donghwi Park[SUP] 6 [/SUP]
Affiliations
- PMID: 32643133
- DOI: 10.1007/s10072-020-04541-z
Abstract
Introduction: In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death.
Methods: In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients.
Results: In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age.
Conclusions: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.
Keywords: Alzheimer’s dementia; COVID-19; Chronic lung disease; Coronavirus.