tetano
Editor, Senior Moderator
Neurol Sci
. 2022 Oct 26.
doi: 10.1007/s10072-022-06429-6. Online ahead of print.
COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)
Filippo Martinelli-Boneschi[SUP] 1 2 [/SUP], Antonio Colombo[SUP] 3 [/SUP], Nereo Bresolin[SUP] 4 5 [/SUP], Maria Sessa[SUP] 6 [/SUP], Pietro Bassi[SUP] 7 [/SUP], Giampiero Grampa[SUP] 8 [/SUP], Eugenio Magni[SUP] 9 [/SUP], Maurizio Versino[SUP] 10 [/SUP], Carlo Ferrarese[SUP] 11 [/SUP], Davide Zarcone[SUP] 12 [/SUP], Alberto Albanese[SUP] 13 [/SUP], Giuseppe Micieli[SUP] 14 [/SUP], Carla Zanferrari[SUP] 15 [/SUP], Antonio Cagnana[SUP] 16 [/SUP], Claudio Ferrante[SUP] 17 [/SUP], Angelo Zilioli[SUP] 18 [/SUP], Davide Locatelli[SUP] 19 [/SUP], Maria Vittoria Calloni[SUP] 20 [/SUP], Maria Luisa Delodovici[SUP] 10 21 [/SUP], Mattia Pozzato[SUP] 4 5 [/SUP], Valerio Patisso[SUP] 4 5 [/SUP], Francesco Bortolan[SUP] 22 [/SUP], Camillo Foresti[SUP] 6 [/SUP], Barbara Frigeni[SUP] 6 [/SUP], Stefania Canella[SUP] 7 [/SUP], Rubjona Xhani[SUP] 8 [/SUP], Massimo Crabbio[SUP] 9 [/SUP], Alessandro Clemenzi[SUP] 10 [/SUP], Marco Mauri[SUP] 10 [/SUP], Simone Beretta[SUP] 11 [/SUP], Isidoro La Spina[SUP] 12 [/SUP], Simona Bernasconi[SUP] 12 [/SUP], Tiziana De Santis[SUP] 13 [/SUP], Anna Cavallini[SUP] 14 [/SUP], Michela Ranieri[SUP] 15 [/SUP], Elisabetta D'Adda[SUP] 16 [/SUP], Maria Elisa Fruguglietti[SUP] 16 [/SUP], Lorenzo Peverelli[SUP] 18 [/SUP], Edoardo Agosti[SUP] 19 [/SUP], Olivia Leoni[SUP] 22 [/SUP], Andrea Rigamonti[SUP] 23 [/SUP], Andrea Salmaggi[SUP] 24 [/SUP]
Affiliations
Abstract
Objective: To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the first pandemic wave, Lombardia.
Methods: Adult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).
Results: Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia.
Conclusions: We detected an increased incidence of GBS in COVID-19 patients which can reflect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures.
Keywords: COVID-19; Coronavirus infections; Guillain-Barré syndrome; SARS-CoV-2 infection.
. 2022 Oct 26.
doi: 10.1007/s10072-022-06429-6. Online ahead of print.
COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)
Filippo Martinelli-Boneschi[SUP] 1 2 [/SUP], Antonio Colombo[SUP] 3 [/SUP], Nereo Bresolin[SUP] 4 5 [/SUP], Maria Sessa[SUP] 6 [/SUP], Pietro Bassi[SUP] 7 [/SUP], Giampiero Grampa[SUP] 8 [/SUP], Eugenio Magni[SUP] 9 [/SUP], Maurizio Versino[SUP] 10 [/SUP], Carlo Ferrarese[SUP] 11 [/SUP], Davide Zarcone[SUP] 12 [/SUP], Alberto Albanese[SUP] 13 [/SUP], Giuseppe Micieli[SUP] 14 [/SUP], Carla Zanferrari[SUP] 15 [/SUP], Antonio Cagnana[SUP] 16 [/SUP], Claudio Ferrante[SUP] 17 [/SUP], Angelo Zilioli[SUP] 18 [/SUP], Davide Locatelli[SUP] 19 [/SUP], Maria Vittoria Calloni[SUP] 20 [/SUP], Maria Luisa Delodovici[SUP] 10 21 [/SUP], Mattia Pozzato[SUP] 4 5 [/SUP], Valerio Patisso[SUP] 4 5 [/SUP], Francesco Bortolan[SUP] 22 [/SUP], Camillo Foresti[SUP] 6 [/SUP], Barbara Frigeni[SUP] 6 [/SUP], Stefania Canella[SUP] 7 [/SUP], Rubjona Xhani[SUP] 8 [/SUP], Massimo Crabbio[SUP] 9 [/SUP], Alessandro Clemenzi[SUP] 10 [/SUP], Marco Mauri[SUP] 10 [/SUP], Simone Beretta[SUP] 11 [/SUP], Isidoro La Spina[SUP] 12 [/SUP], Simona Bernasconi[SUP] 12 [/SUP], Tiziana De Santis[SUP] 13 [/SUP], Anna Cavallini[SUP] 14 [/SUP], Michela Ranieri[SUP] 15 [/SUP], Elisabetta D'Adda[SUP] 16 [/SUP], Maria Elisa Fruguglietti[SUP] 16 [/SUP], Lorenzo Peverelli[SUP] 18 [/SUP], Edoardo Agosti[SUP] 19 [/SUP], Olivia Leoni[SUP] 22 [/SUP], Andrea Rigamonti[SUP] 23 [/SUP], Andrea Salmaggi[SUP] 24 [/SUP]
Affiliations
- PMID: 36289117
- DOI: 10.1007/s10072-022-06429-6
Abstract
Objective: To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the first pandemic wave, Lombardia.
Methods: Adult patients admitted to 20 Neurological Units between 1/3-30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO).
Results: Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia.
Conclusions: We detected an increased incidence of GBS in COVID-19 patients which can reflect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures.
Keywords: COVID-19; Coronavirus infections; Guillain-Barré syndrome; SARS-CoV-2 infection.