tetano
Editor, Senior Moderator
Neurol Sci
. 2020 Oct 9.
doi: 10.1007/s10072-020-04795-7. Online ahead of print.
Brain microvascular occlusive disorder in COVID-19: a case report
Laura Saitta[SUP] 1 [/SUP], Alexandre Molin[SUP] 2 [/SUP], Flavio Villani[SUP] 3 [/SUP], Angelo Insorsi[SUP] 2 [/SUP], Luca Roccatagliata[SUP] 1 4 [/SUP], Matilde Inglese[SUP] 5 6 [/SUP], Matteo Bassetti[SUP] 4 7 [/SUP], Paolo Pelosi[SUP] 2 8 [/SUP], Lucio Castellan[SUP] 1 [/SUP], Simonetta Gerevini[SUP] 9 [/SUP], Chiara Robba[SUP] 10 [/SUP], Nicol? Patroniti[SUP] 2 8 [/SUP]
Affiliations
Abstract
We describe the case of a COVID-19 patient with severely impaired consciousness after sedation hold, showing magnetic resonance imaging (MRI) findings of (i) acute bilateral supratentorial ischemic lesions involving the fronto-parietal white matter and the corpus callosum and (ii) multiple diffuse susceptibility weighted imaging (SWI) hypointense foci, infra and supratentorial, predominantly bithalamic, suggestive of microhemorrhage or alternatively microthrombi. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA was detected in the cerebrospinal fluid. Our findings suggest the occurrence of vascular damage, predominantly involving microvessels. The underlying mechanisms, which include direct and indirect penetration of the virus to the central nervous system and systemic cardiorespiratory complications, are yet to be elucidated, and a direct correlation with SARS-CoV-2 infection remains uncertain.
Keywords: Coagulopathy; Covid-19; Inflammation; Ischemia; Microthrombi; Neurological complications.
. 2020 Oct 9.
doi: 10.1007/s10072-020-04795-7. Online ahead of print.
Brain microvascular occlusive disorder in COVID-19: a case report
Laura Saitta[SUP] 1 [/SUP], Alexandre Molin[SUP] 2 [/SUP], Flavio Villani[SUP] 3 [/SUP], Angelo Insorsi[SUP] 2 [/SUP], Luca Roccatagliata[SUP] 1 4 [/SUP], Matilde Inglese[SUP] 5 6 [/SUP], Matteo Bassetti[SUP] 4 7 [/SUP], Paolo Pelosi[SUP] 2 8 [/SUP], Lucio Castellan[SUP] 1 [/SUP], Simonetta Gerevini[SUP] 9 [/SUP], Chiara Robba[SUP] 10 [/SUP], Nicol? Patroniti[SUP] 2 8 [/SUP]
Affiliations
- PMID: 33034804
- DOI: 10.1007/s10072-020-04795-7
Abstract
We describe the case of a COVID-19 patient with severely impaired consciousness after sedation hold, showing magnetic resonance imaging (MRI) findings of (i) acute bilateral supratentorial ischemic lesions involving the fronto-parietal white matter and the corpus callosum and (ii) multiple diffuse susceptibility weighted imaging (SWI) hypointense foci, infra and supratentorial, predominantly bithalamic, suggestive of microhemorrhage or alternatively microthrombi. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA was detected in the cerebrospinal fluid. Our findings suggest the occurrence of vascular damage, predominantly involving microvessels. The underlying mechanisms, which include direct and indirect penetration of the virus to the central nervous system and systemic cardiorespiratory complications, are yet to be elucidated, and a direct correlation with SARS-CoV-2 infection remains uncertain.
Keywords: Coagulopathy; Covid-19; Inflammation; Ischemia; Microthrombi; Neurological complications.