Giuseppe
Emeritus
Memory CD4+ T cells induce innate responses independently of pathogen (Nature Medicine, abstract, edited)
[Source: Nature, <cite cite="http://www.nature.com/nm/journal/v16/n5/abs/nm.2142.html#/">Memory CD4+ T cells induce innate responses independently of pathogen : Nature Medicine : Nature Publishing Group</cite>. Abstract, edited.]
Memory CD4+ T cells induce innate responses independently of pathogen
* Tara M Strutt, * K Kai McKinstry, * John P Dibble, * Caylin Winchell, * Yi Kuang, * Jonathan D Curtis, * Gail Huston, * Richard W Dutton * & Susan L Swain
Journal name: Nature Medicine
Volume: 16, Pages: 558?564
Year published: (2010)
DOI: doi:10.1038/nm.2142
Received 09 September 2009
Accepted 19 March 2010
Published online 02 May 2010
Abstract
Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. We found that the response of memory, but not naive, CD4+ T cells enhances production of multiple innate inflammatory cytokines and chemokines (IICs) in the lung and that, during influenza infection, this leads to early control of virus. Memory CD4+ T cell?induced IICs and viral control require cognate antigen recognition and are optimal when memory cells are either T helper type 1 (TH1) or TH17 polarized but are independent of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) production and do not require activation of conserved pathogen recognition pathways. This represents a previously undescribed mechanism by which memory CD4+ T cells induce an early innate response that enhances immune protection against pathogens.
-
-----
[Source: Nature, <cite cite="http://www.nature.com/nm/journal/v16/n5/abs/nm.2142.html#/">Memory CD4+ T cells induce innate responses independently of pathogen : Nature Medicine : Nature Publishing Group</cite>. Abstract, edited.]
Memory CD4+ T cells induce innate responses independently of pathogen
* Tara M Strutt, * K Kai McKinstry, * John P Dibble, * Caylin Winchell, * Yi Kuang, * Jonathan D Curtis, * Gail Huston, * Richard W Dutton * & Susan L Swain
Journal name: Nature Medicine
Volume: 16, Pages: 558?564
Year published: (2010)
DOI: doi:10.1038/nm.2142
Received 09 September 2009
Accepted 19 March 2010
Published online 02 May 2010
Abstract
Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. We found that the response of memory, but not naive, CD4+ T cells enhances production of multiple innate inflammatory cytokines and chemokines (IICs) in the lung and that, during influenza infection, this leads to early control of virus. Memory CD4+ T cell?induced IICs and viral control require cognate antigen recognition and are optimal when memory cells are either T helper type 1 (TH1) or TH17 polarized but are independent of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) production and do not require activation of conserved pathogen recognition pathways. This represents a previously undescribed mechanism by which memory CD4+ T cells induce an early innate response that enhances immune protection against pathogens.
-
-----