Tonka
Well-known member
http://www.diariohoy.net/accion-verNota-id-60561-titulo-Proteínas_contra_el_dengue_y_la_gripe_A
Natural defense-Protein against dengue and influenza A
A scientific research is to increase the body's natural antibodies to fight the spread of influenza A virus and the disease is caused by the mosquito. Experts hope to use the results for therapeutic purposes
While the proliferation of mosquitoes and the appearance of the first dengue cases turned on the alarm in our country, a group of scientists discovered a natural defense mechanism not only against the disease, but also against an even more dangerous influenza A.
The research, conducted by U.S. experts and published in the website of Spanish newspaper El Mundo, was proposed in order to describe the entire family of proteins designed to prevent viruses such as H1N1 influenza A and dengue infected host cells. As you know, when levels of these molecules, whose name is IFITM-3, replication of these microorganisms is inhibited. For this reason, scientists estimate that an increase in the production of these proteins can be effective in curing infection.
The genome of most viruses is small and has little capacity to generate proteins need to borrow host proteins to develop. The H1N1 virus that causes influenza is capable of encoding only 11 proteins. Therefore, these agents need to hijack the production of some host proteins to complete its life cycle and to replicate. So far, studies have focused primarily on analyzing the function of molecules generated by the virus itself, but not the target proteins.
Team authors Howard Hughes Medical Institute of Harvard Medical School in the U.S., said "the mission of the infected cell protein is not known just" and therefore were suggested to find those host molecules that are essential for the H1N1 being played, a phenomenon essential for the infection from spreading. The experimental group consisted of using small interfering RNAs (which are a vital part of the immune response to viruses and other genetic material different from the body) and thus blocked a one the production of these proteins and could observe the reaction of the virus to their absence. According to statistics, so far the influenza virus A (H1N1) to cause 8,000 deaths worldwide over the past seven months.
About the aedes
The research of Harvard University, the mission doomed to analyze proteins that have an infected cell to counteract the presence of the virus, it may be helpful for achieving a breakthrough in treating dengue. Remember that in December so far, Argentina has already registered three cases of this disease: one in the Buenos Aires district of San Nicolas and the others in the provinces of Santa Fe and Misiones. Health officials said the three patients were infected while traveling overseas, but the danger is that the mosquito that transmits the evil-Aedes aegypti, also lives in our country. Worse still is a household insect habits, whose presence is quite common in La Plata and its surroundings.
The presence of this disease in our latitudes cause for much concern among the population and require extreme precautionary measures to avoid contracting it. As is known, no specific drugs to address dengue infection and treatment emphasis is primarily on relief of symptoms. Nor are there shots and are estimated to be spent between 5 and 10 years before an effective antidote is available against dengue for public use.
In order to find a solution to dengue and influenza, U.S. scientists focused their efforts on investigating the innate mechanisms that the human body has to counter the spread of these viruses. During the investigation, they identified more than 120 molecules that the influenza A virus needs to replicate. Within the complex group a powerfully captured the attention of scientists: IFITM, a group of proteins first described 25 years ago. With this experiment were able to determine that increasing the presence of the protein was achieved IFITM3 be fortified cells to diminish the spread of the H1N1 virus that causes influenza, the common flu and dengue virus.
Experience also moved to investigate whether the increase could generate IFTM3 regression in other viral diseases such as hepatitis C or AIDS. Unfortunately, your application was not a reversal of the viruses that cause these diseases.
Regarding the results, researchers are optimistic for a new approach to address the treatment of influenza A and dengue fever. In this regard raised go beyond the laboratory situation and use these results for therapeutic purposes.
Natural defense-Protein against dengue and influenza A
A scientific research is to increase the body's natural antibodies to fight the spread of influenza A virus and the disease is caused by the mosquito. Experts hope to use the results for therapeutic purposes
While the proliferation of mosquitoes and the appearance of the first dengue cases turned on the alarm in our country, a group of scientists discovered a natural defense mechanism not only against the disease, but also against an even more dangerous influenza A.
The research, conducted by U.S. experts and published in the website of Spanish newspaper El Mundo, was proposed in order to describe the entire family of proteins designed to prevent viruses such as H1N1 influenza A and dengue infected host cells. As you know, when levels of these molecules, whose name is IFITM-3, replication of these microorganisms is inhibited. For this reason, scientists estimate that an increase in the production of these proteins can be effective in curing infection.
The genome of most viruses is small and has little capacity to generate proteins need to borrow host proteins to develop. The H1N1 virus that causes influenza is capable of encoding only 11 proteins. Therefore, these agents need to hijack the production of some host proteins to complete its life cycle and to replicate. So far, studies have focused primarily on analyzing the function of molecules generated by the virus itself, but not the target proteins.
Team authors Howard Hughes Medical Institute of Harvard Medical School in the U.S., said "the mission of the infected cell protein is not known just" and therefore were suggested to find those host molecules that are essential for the H1N1 being played, a phenomenon essential for the infection from spreading. The experimental group consisted of using small interfering RNAs (which are a vital part of the immune response to viruses and other genetic material different from the body) and thus blocked a one the production of these proteins and could observe the reaction of the virus to their absence. According to statistics, so far the influenza virus A (H1N1) to cause 8,000 deaths worldwide over the past seven months.
About the aedes
The research of Harvard University, the mission doomed to analyze proteins that have an infected cell to counteract the presence of the virus, it may be helpful for achieving a breakthrough in treating dengue. Remember that in December so far, Argentina has already registered three cases of this disease: one in the Buenos Aires district of San Nicolas and the others in the provinces of Santa Fe and Misiones. Health officials said the three patients were infected while traveling overseas, but the danger is that the mosquito that transmits the evil-Aedes aegypti, also lives in our country. Worse still is a household insect habits, whose presence is quite common in La Plata and its surroundings.
The presence of this disease in our latitudes cause for much concern among the population and require extreme precautionary measures to avoid contracting it. As is known, no specific drugs to address dengue infection and treatment emphasis is primarily on relief of symptoms. Nor are there shots and are estimated to be spent between 5 and 10 years before an effective antidote is available against dengue for public use.
In order to find a solution to dengue and influenza, U.S. scientists focused their efforts on investigating the innate mechanisms that the human body has to counter the spread of these viruses. During the investigation, they identified more than 120 molecules that the influenza A virus needs to replicate. Within the complex group a powerfully captured the attention of scientists: IFITM, a group of proteins first described 25 years ago. With this experiment were able to determine that increasing the presence of the protein was achieved IFITM3 be fortified cells to diminish the spread of the H1N1 virus that causes influenza, the common flu and dengue virus.
Experience also moved to investigate whether the increase could generate IFTM3 regression in other viral diseases such as hepatitis C or AIDS. Unfortunately, your application was not a reversal of the viruses that cause these diseases.
Regarding the results, researchers are optimistic for a new approach to address the treatment of influenza A and dengue fever. In this regard raised go beyond the laboratory situation and use these results for therapeutic purposes.