tetano
Editor, Senior Moderator
Nat Med
. 2021 Feb 8.
doi: 10.1038/s41591-021-01270-4. Online ahead of print.
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera
Xuping Xie[SUP] #[/SUP][SUP] 1 [/SUP], Yang Liu[SUP] #[/SUP][SUP] 1 [/SUP], Jianying Liu[SUP] #[/SUP][SUP] 2 3 [/SUP], Xianwen Zhang[SUP] 1 [/SUP], Jing Zou[SUP] 1 [/SUP], Camila R Fontes-Garfias[SUP] 1 [/SUP], Hongjie Xia[SUP] 1 [/SUP], Kena A Swanson[SUP] 4 [/SUP], Mark Cutler[SUP] 4 [/SUP], David Cooper[SUP] 4 [/SUP], Vineet D Menachery[SUP] 2 3 [/SUP], Scott C Weaver[SUP] 2 3 [/SUP], Philip R Dormitzer[SUP] 5 [/SUP], Pei-Yong Shi[SUP] 6 7 8 9 10 [/SUP]
Affiliations
Abstract
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
. 2021 Feb 8.
doi: 10.1038/s41591-021-01270-4. Online ahead of print.
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera
Xuping Xie[SUP] #[/SUP][SUP] 1 [/SUP], Yang Liu[SUP] #[/SUP][SUP] 1 [/SUP], Jianying Liu[SUP] #[/SUP][SUP] 2 3 [/SUP], Xianwen Zhang[SUP] 1 [/SUP], Jing Zou[SUP] 1 [/SUP], Camila R Fontes-Garfias[SUP] 1 [/SUP], Hongjie Xia[SUP] 1 [/SUP], Kena A Swanson[SUP] 4 [/SUP], Mark Cutler[SUP] 4 [/SUP], David Cooper[SUP] 4 [/SUP], Vineet D Menachery[SUP] 2 3 [/SUP], Scott C Weaver[SUP] 2 3 [/SUP], Philip R Dormitzer[SUP] 5 [/SUP], Pei-Yong Shi[SUP] 6 7 8 9 10 [/SUP]
Affiliations
- PMID: 33558724
- DOI: 10.1038/s41591-021-01270-4
Abstract
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.