tetano
Editor, Senior Moderator
Nat Med
. 2021 Jun 23.
doi: 10.1038/s41591-021-01433-3. Online ahead of print.
Long COVID in a prospective cohort of home-isolated patients
Bjørn Blomberg[SUP] 1 2 3 [/SUP], Kristin Greve-Isdahl Mohn[SUP] 4 5 [/SUP], Karl Albert Brokstad[SUP] 6 7 [/SUP], Fan Zhou[SUP] 5 [/SUP], Dagrun Waag Linchausen[SUP] 8 [/SUP], Bent-Are Hansen[SUP] 9 [/SUP], Sarah Lartey[SUP] 5 [/SUP], Therese Bredholt Onyango[SUP] 5 [/SUP], Kanika Kuwelker[SUP] 10 11 4 5 [/SUP], Marianne Sævik[SUP] 4 [/SUP], Hauke Bartsch[SUP] 12 13 [/SUP], Camilla Tøndel[SUP] 14 15 [/SUP], Bård Reiakvam Kittang[SUP] 10 9 [/SUP], Bergen COVID-19 Research Group; Rebecca Jane Cox[SUP] #[/SUP][SUP] 16 17 [/SUP], Nina Langeland[SUP] #[/SUP][SUP] 18 19 20 [/SUP]
Collaborators, Affiliations
Abstract
Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients-247 home-isolated and 65 hospitalized-comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16-30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.
. 2021 Jun 23.
doi: 10.1038/s41591-021-01433-3. Online ahead of print.
Long COVID in a prospective cohort of home-isolated patients
Bjørn Blomberg[SUP] 1 2 3 [/SUP], Kristin Greve-Isdahl Mohn[SUP] 4 5 [/SUP], Karl Albert Brokstad[SUP] 6 7 [/SUP], Fan Zhou[SUP] 5 [/SUP], Dagrun Waag Linchausen[SUP] 8 [/SUP], Bent-Are Hansen[SUP] 9 [/SUP], Sarah Lartey[SUP] 5 [/SUP], Therese Bredholt Onyango[SUP] 5 [/SUP], Kanika Kuwelker[SUP] 10 11 4 5 [/SUP], Marianne Sævik[SUP] 4 [/SUP], Hauke Bartsch[SUP] 12 13 [/SUP], Camilla Tøndel[SUP] 14 15 [/SUP], Bård Reiakvam Kittang[SUP] 10 9 [/SUP], Bergen COVID-19 Research Group; Rebecca Jane Cox[SUP] #[/SUP][SUP] 16 17 [/SUP], Nina Langeland[SUP] #[/SUP][SUP] 18 19 20 [/SUP]
Collaborators, Affiliations
- PMID: 34163090
- DOI: 10.1038/s41591-021-01433-3
Abstract
Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients-247 home-isolated and 65 hospitalized-comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16-30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.