tetano
Editor, Senior Moderator
Nat Commun
. 2025 Jul 24;16(1):6829.
doi: 10.1038/s41467-025-61961-1. Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis
Yiwen Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jiayi Tong[SUP] #[/SUP][SUP] 1 3 4 [/SUP], Dazheng Zhang[SUP] #[/SUP][SUP] 1 3 [/SUP], Jiajie Chen[SUP] 1 3 [/SUP], Lu Li[SUP] 1 2 [/SUP], Yuqing Lei[SUP] 1 3 [/SUP], Ting Zhou[SUP] 1 3 [/SUP], Leyna V Aragon[SUP] 5 6 [/SUP], Michael J Becich[SUP] 7 [/SUP], Saul Blecker[SUP] 8 [/SUP], Nathan J Blum[SUP] 9 [/SUP], Dimitri A Christakis[SUP] 10 [/SUP], Mady Hornig[SUP] 5 11 [/SUP], Maxwell M Hornig-Rohan[SUP] 5 [/SUP], Ravi Jhaveri[SUP] 12 [/SUP], W Schuyler Jones[SUP] 13 [/SUP], Amber Brown Keebler[SUP] 14 [/SUP], Kelly Kelleher[SUP] 15 [/SUP], Susan Kim[SUP] 16 [/SUP], Abu Saleh Mohammad Mosa[SUP] 17 18 [/SUP], Kathleen Pajer[SUP] 19 [/SUP], Jonathan Platt[SUP] 20 [/SUP], Hayden T Schwenk[SUP] 21 [/SUP], Bradley W Taylor[SUP] 22 [/SUP], Levon H Utidjian[SUP] 23 [/SUP], David A Williams[SUP] 24 [/SUP], Raghuram Prasad[SUP] 25 [/SUP], Josephine Elia[SUP] 26 [/SUP], Christopher B Forrest[SUP] 23 [/SUP], Yong Chen[SUP] 27 28 29 30 31 32 [/SUP]
Affiliations
The COVID-19 pandemic has been associated with increased neuropsychiatric conditions in children and youths, with evidence suggesting that SARS-CoV-2 infection may contribute additional risks beyond pandemic stressors. This study aims to assess the full spectrum of neuropsychiatric conditions in COVID-19 positive children (ages 5-12) and youths (ages 12-20) compared to a matched COVID-19 negative cohort, accounting for factors influencing infection risk. Using EHR data from 25 institutions in the RECOVER program, we conduct a retrospective analysis of 326,074 COVID-19 positive and 887,314 negative participants matched for risk factors and stratified by age. Neuropsychiatric outcomes are examined 28 to 179 days post-infection or negative test between March 2020 and December 2022. SARS-CoV-2 positivity is confirmed via PCR, serology, or antigen tests, while negativity requires negative test results and no related diagnoses. Risk differences reveal higher frequencies of neuropsychiatric conditions in the COVID-19 positive cohort. Children face increased risks for anxiety, OCD, ADHD, autism, and other conditions, while youths exhibit elevated risks for anxiety, suicidality, depression, and related symptoms. These findings highlight SARS-CoV-2 infection as a potential contributor to neuropsychiatric risks, emphasizing the importance of research into tailored treatments and preventive strategies for affected individuals.
. 2025 Jul 24;16(1):6829.
doi: 10.1038/s41467-025-61961-1. Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis
Yiwen Lu[SUP] #[/SUP][SUP] 1 2 [/SUP], Jiayi Tong[SUP] #[/SUP][SUP] 1 3 4 [/SUP], Dazheng Zhang[SUP] #[/SUP][SUP] 1 3 [/SUP], Jiajie Chen[SUP] 1 3 [/SUP], Lu Li[SUP] 1 2 [/SUP], Yuqing Lei[SUP] 1 3 [/SUP], Ting Zhou[SUP] 1 3 [/SUP], Leyna V Aragon[SUP] 5 6 [/SUP], Michael J Becich[SUP] 7 [/SUP], Saul Blecker[SUP] 8 [/SUP], Nathan J Blum[SUP] 9 [/SUP], Dimitri A Christakis[SUP] 10 [/SUP], Mady Hornig[SUP] 5 11 [/SUP], Maxwell M Hornig-Rohan[SUP] 5 [/SUP], Ravi Jhaveri[SUP] 12 [/SUP], W Schuyler Jones[SUP] 13 [/SUP], Amber Brown Keebler[SUP] 14 [/SUP], Kelly Kelleher[SUP] 15 [/SUP], Susan Kim[SUP] 16 [/SUP], Abu Saleh Mohammad Mosa[SUP] 17 18 [/SUP], Kathleen Pajer[SUP] 19 [/SUP], Jonathan Platt[SUP] 20 [/SUP], Hayden T Schwenk[SUP] 21 [/SUP], Bradley W Taylor[SUP] 22 [/SUP], Levon H Utidjian[SUP] 23 [/SUP], David A Williams[SUP] 24 [/SUP], Raghuram Prasad[SUP] 25 [/SUP], Josephine Elia[SUP] 26 [/SUP], Christopher B Forrest[SUP] 23 [/SUP], Yong Chen[SUP] 27 28 29 30 31 32 [/SUP]
Affiliations
- PMID: 40707478
- DOI: 10.1038/s41467-025-61961-1
The COVID-19 pandemic has been associated with increased neuropsychiatric conditions in children and youths, with evidence suggesting that SARS-CoV-2 infection may contribute additional risks beyond pandemic stressors. This study aims to assess the full spectrum of neuropsychiatric conditions in COVID-19 positive children (ages 5-12) and youths (ages 12-20) compared to a matched COVID-19 negative cohort, accounting for factors influencing infection risk. Using EHR data from 25 institutions in the RECOVER program, we conduct a retrospective analysis of 326,074 COVID-19 positive and 887,314 negative participants matched for risk factors and stratified by age. Neuropsychiatric outcomes are examined 28 to 179 days post-infection or negative test between March 2020 and December 2022. SARS-CoV-2 positivity is confirmed via PCR, serology, or antigen tests, while negativity requires negative test results and no related diagnoses. Risk differences reveal higher frequencies of neuropsychiatric conditions in the COVID-19 positive cohort. Children face increased risks for anxiety, OCD, ADHD, autism, and other conditions, while youths exhibit elevated risks for anxiety, suicidality, depression, and related symptoms. These findings highlight SARS-CoV-2 infection as a potential contributor to neuropsychiatric risks, emphasizing the importance of research into tailored treatments and preventive strategies for affected individuals.