tetano
Editor, Senior Moderator
Nat Commun
. 2024 May 27;15(1):4499.
doi: 10.1038/s41467-024-48825-w. Acute and post-acute respiratory complications of SARS-CoV-2 infection: population-based cohort study in South Korea and Japan
Yujin Choi[SUP] #[/SUP][SUP] 1 2 [/SUP], Hyeon Jin Kim[SUP] #[/SUP][SUP] 1 3 [/SUP], Jaeyu Park[SUP] #[/SUP][SUP] 1 3 [/SUP], Myeongcheol Lee[SUP] 1 3 [/SUP], Sunyoung Kim[SUP] 4 [/SUP], Ai Koyanagi[SUP] 5 [/SUP], Lee Smith[SUP] 6 [/SUP], Min Seo Kim[SUP] 7 [/SUP], Masoud Rahmati[SUP] 8 9 10 [/SUP], Hayeon Lee[SUP] 11 [/SUP], Jiseung Kang[SUP] 12 13 [/SUP], Dong Keon Yon[SUP] 14 15 16 [/SUP]
Affiliations
Considering the significant burden of post-acute COVID-19 conditions among patients infected with SARS-CoV-2, we aimed to identify the risk of acute respiratory complications or post-acute respiratory sequelae. A binational population-based cohort study was conducted to analyze the risk of acute respiratory complications or post-acute respiratory sequelae after SARS-CoV-2 infection. We used a Korean nationwide claim-based cohort (K-COV-N; n = 2,312,748; main cohort) and a Japanese claim-based cohort (JMDC; n = 3,115,606; replication cohort) after multi-to-one propensity score matching. Among 2,312,748 Korean participants (mean age, 47.2 years [SD, 15.6]; 1,109,708 [48.0%] female), 17.1% (394,598/2,312,748) were infected with SARS-CoV-2. The risk of acute respiratory complications or post-acute respiratory sequelae is significantly increased in people with SARS-CoV-2 infection compared to the general population (acute respiratory complications: HR, 8.06 [95% CI, 6.92-9.38]; post-acute respiratory sequelae: 1.68 [1.62-1.75]), and the risk increased with increasing COVID-19 severity. We identified COVID-19 vaccination as an attenuating factor, showing a protective association against acute or post-acute respiratory conditions. Furthermore, while the excess post-acute risk diminished with time following SARS-CoV-2 infection, it persisted beyond 6 months post-infection. The replication cohort showed a similar pattern in the association. Our study comprehensively evaluates respiratory complications in post-COVID-19 conditions, considering attenuating factors such as vaccination status, post-infection duration, COVID-19 severity, and specific respiratory conditions.
. 2024 May 27;15(1):4499.
doi: 10.1038/s41467-024-48825-w. Acute and post-acute respiratory complications of SARS-CoV-2 infection: population-based cohort study in South Korea and Japan
Yujin Choi[SUP] #[/SUP][SUP] 1 2 [/SUP], Hyeon Jin Kim[SUP] #[/SUP][SUP] 1 3 [/SUP], Jaeyu Park[SUP] #[/SUP][SUP] 1 3 [/SUP], Myeongcheol Lee[SUP] 1 3 [/SUP], Sunyoung Kim[SUP] 4 [/SUP], Ai Koyanagi[SUP] 5 [/SUP], Lee Smith[SUP] 6 [/SUP], Min Seo Kim[SUP] 7 [/SUP], Masoud Rahmati[SUP] 8 9 10 [/SUP], Hayeon Lee[SUP] 11 [/SUP], Jiseung Kang[SUP] 12 13 [/SUP], Dong Keon Yon[SUP] 14 15 16 [/SUP]
Affiliations
- PMID: 38802352
- DOI: 10.1038/s41467-024-48825-w
Considering the significant burden of post-acute COVID-19 conditions among patients infected with SARS-CoV-2, we aimed to identify the risk of acute respiratory complications or post-acute respiratory sequelae. A binational population-based cohort study was conducted to analyze the risk of acute respiratory complications or post-acute respiratory sequelae after SARS-CoV-2 infection. We used a Korean nationwide claim-based cohort (K-COV-N; n = 2,312,748; main cohort) and a Japanese claim-based cohort (JMDC; n = 3,115,606; replication cohort) after multi-to-one propensity score matching. Among 2,312,748 Korean participants (mean age, 47.2 years [SD, 15.6]; 1,109,708 [48.0%] female), 17.1% (394,598/2,312,748) were infected with SARS-CoV-2. The risk of acute respiratory complications or post-acute respiratory sequelae is significantly increased in people with SARS-CoV-2 infection compared to the general population (acute respiratory complications: HR, 8.06 [95% CI, 6.92-9.38]; post-acute respiratory sequelae: 1.68 [1.62-1.75]), and the risk increased with increasing COVID-19 severity. We identified COVID-19 vaccination as an attenuating factor, showing a protective association against acute or post-acute respiratory conditions. Furthermore, while the excess post-acute risk diminished with time following SARS-CoV-2 infection, it persisted beyond 6 months post-infection. The replication cohort showed a similar pattern in the association. Our study comprehensively evaluates respiratory complications in post-COVID-19 conditions, considering attenuating factors such as vaccination status, post-infection duration, COVID-19 severity, and specific respiratory conditions.