Nat.Com: Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells

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[h=1]Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8[SUP]+[/SUP] T cells[/h]

• Zhongfang Wang,
• Yanmin Wan,
• Chenli Qiu,
• Sergio Qui?ones-Parra,
• Zhaoqin Zhu,
• Liyen Loh,
• Di Tian,
• Yanqin Ren,
• Yunwen Hu,
• Xiaoyan Zhang,
• Paul G. Thomas,
• Michael Inouye,
• Peter C. Doherty,
• Katherine Kedzierska
• & Jianqing Xu

[h=1]Abstract[/h] The avian origin A/H7N9 influenza virus causes high admission rates (>99%) and mortality (>30%), with ultimately favourable outcomes ranging from rapid recovery to prolonged hospitalization. Using a multicolour assay for monitoring adaptive and innate immunity, here we dissect the kinetic emergence of different effector mechanisms across the spectrum of H7N9 disease and recovery. We find that a diversity of response mechanisms contribute to resolution and survival. Patients discharged within 2?3 weeks have early prominent H7N9-specific CD8[SUP]+[/SUP] T-cell responses, while individuals with prolonged hospital stays have late recruitment of CD8[SUP]+[/SUP]/CD4[SUP]+[/SUP] T cells and antibodies simultaneously (recovery by week 4), augmented even later by prominent NK cell responses (recovery >30 days). In contrast, those who succumbed have minimal influenza-specific immunity and little evidence of T-cell activation. Our study illustrates the importance of robust CD8[SUP]+[/SUP] T-cell memory for protection against severe influenza disease caused by newly emerging influenza A viruses.


full article

http://www.nature.com/ncomms/2015/150513/ncomms7833/full/ncomms7833.html#close