Shiloh
Editor, Senior Moderator
Source: http://7thspace.com/headlines/45864...ra_genotypic_evolution_of_enterovirus_71.html
Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbreaks during 1998-2008 in Taiwan, genotype B5 was responsible for two large outbreaks in 2008 and 2012, respectively.
In China, by contrast, EV71 often persists as a single genotype in the population and causes frequent outbreaks. To investigate genetic changes in viral evolution, complete EV71 genome sequences were used to analyze the intra-genotypic evolution pattern in Taiwan, China, and the Netherlands...
...Conclusions: Unlike VP1 coding sequences long used for phylogenetic study of enteroviruses due to expected host immune escape, our study emphasizes a dominant role of non-synonymous mutations in non-structural protein regions that contribute to (re-)emergent genotypes in continuous stepwise evolution.
Dozens of amino acid substitutions, especially in non-structural proteins, were identified via genetic changes driven through intra-genotypic evolution worldwide. These identified substitutions appeared to increase viral fitness in the population, affording valuable insights not only for viral evolution but also for prevention, control, and vaccine against EV71 infection.
Author: Sheng-Wen HuangHui-Li ChengHsin-Yi HsiehChia-Lun ChangHuey-Pin TsaiPin-Hwa KuoShih-Min WangChing-Chuan LiuIh-Jen SuJen-Ren Wang
Credits/Source: Journal of Biomedical Science 2014, 21:33
Published on: 2014-04-26
Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbreaks during 1998-2008 in Taiwan, genotype B5 was responsible for two large outbreaks in 2008 and 2012, respectively.
In China, by contrast, EV71 often persists as a single genotype in the population and causes frequent outbreaks. To investigate genetic changes in viral evolution, complete EV71 genome sequences were used to analyze the intra-genotypic evolution pattern in Taiwan, China, and the Netherlands...
...Conclusions: Unlike VP1 coding sequences long used for phylogenetic study of enteroviruses due to expected host immune escape, our study emphasizes a dominant role of non-synonymous mutations in non-structural protein regions that contribute to (re-)emergent genotypes in continuous stepwise evolution.
Dozens of amino acid substitutions, especially in non-structural proteins, were identified via genetic changes driven through intra-genotypic evolution worldwide. These identified substitutions appeared to increase viral fitness in the population, affording valuable insights not only for viral evolution but also for prevention, control, and vaccine against EV71 infection.
Author: Sheng-Wen HuangHui-Li ChengHsin-Yi HsiehChia-Lun ChangHuey-Pin TsaiPin-Hwa KuoShih-Min WangChing-Chuan LiuIh-Jen SuJen-Ren Wang
Credits/Source: Journal of Biomedical Science 2014, 21:33
Published on: 2014-04-26