tetano
Editor, Senior Moderator
Allergy Asthma Clin Immunol. 2017 Dec 13;13:49. doi: 10.1186/s13223-017-0222-9. eCollection 2017.
[h=1]MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination.[/h] Eindhoven S[SUP]1,[/SUP][SUP]2[/SUP], Levels J[SUP]1[/SUP], Huisman M[SUP]3[/SUP], de Winter KR[SUP]4[/SUP], Dalm V[SUP]5,[/SUP][SUP]6[/SUP], Alwani R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).
[h=4]Case report:[/h] We describe the case of a 67-year old man who presented with a myeloperoxidase-ANCA associated vasculitis with renal involvement and mononeuritis multiplex after seasonal influenza vaccination. He was initially treated with intravenous cyclophosphamide and high-dose prednisolone followed by maintenance treatment consisting of azathioprine and prednisolone.
[h=4]Conclusion:[/h] We hypothesize that seasonal influenza vaccination triggered a systemic immune response in a susceptible patient to develop AAV with renal involvement and vasculitic neuropathy. In general, seasonal influenza vaccinations are considered to be safe, however, clinicians should be aware of this rare phenomenon.
[h=4]KEYWORDS:[/h] Anti-neutrophil cytoplasmic antibody (ANCA); Influenza vaccination; Vasculitis
PMID: 29255476 PMCID: PMC5727957 DOI: 10.1186/s13223-017-0222-9
[h=1]MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination.[/h] Eindhoven S[SUP]1,[/SUP][SUP]2[/SUP], Levels J[SUP]1[/SUP], Huisman M[SUP]3[/SUP], de Winter KR[SUP]4[/SUP], Dalm V[SUP]5,[/SUP][SUP]6[/SUP], Alwani R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain-Barre syndrome, rheumatoid arthritis, pemphigus vulgaris, psoriasis, giant cell arteritis and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV).
[h=4]Case report:[/h] We describe the case of a 67-year old man who presented with a myeloperoxidase-ANCA associated vasculitis with renal involvement and mononeuritis multiplex after seasonal influenza vaccination. He was initially treated with intravenous cyclophosphamide and high-dose prednisolone followed by maintenance treatment consisting of azathioprine and prednisolone.
[h=4]Conclusion:[/h] We hypothesize that seasonal influenza vaccination triggered a systemic immune response in a susceptible patient to develop AAV with renal involvement and vasculitic neuropathy. In general, seasonal influenza vaccinations are considered to be safe, however, clinicians should be aware of this rare phenomenon.
[h=4]KEYWORDS:[/h] Anti-neutrophil cytoplasmic antibody (ANCA); Influenza vaccination; Vasculitis
PMID: 29255476 PMCID: PMC5727957 DOI: 10.1186/s13223-017-0222-9