tetano
Editor, Senior Moderator
Eur J Immunol. 2016 Nov 18. doi: 10.1002/eji.201646523. [Epub ahead of print]
[h=1]Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD82 T-cell immunodominance.[/h] Cruz JL[SUP]1[/SUP], P?rez-Gir?n JV[SUP]1[/SUP], L?dtke A[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], G?mez-Medina S[SUP]1[/SUP], Ruibal P[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Idoyaga J[SUP]4[/SUP], Mu?oz-Fontela C[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8[SUP]+[/SUP] T cells and trigger the switch in immunodominance of the CD8[SUP]+[/SUP] T-cell response from acidic polymerase (PA)-specificity to nucleoprotein (NP)-specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] CD8+ T cell; Dendritic cell; Immunodominance; Influenza virus; Monocyte
PMID: 27859043 DOI: 10.1002/eji.201646523
[PubMed - as supplied by publisher]
[h=1]Monocyte-derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD82 T-cell immunodominance.[/h] Cruz JL[SUP]1[/SUP], P?rez-Gir?n JV[SUP]1[/SUP], L?dtke A[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], G?mez-Medina S[SUP]1[/SUP], Ruibal P[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Idoyaga J[SUP]4[/SUP], Mu?oz-Fontela C[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus infection triggers an increase in the number of monocyte-derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8[SUP]+[/SUP] T cells and trigger the switch in immunodominance of the CD8[SUP]+[/SUP] T-cell response from acidic polymerase (PA)-specificity to nucleoprotein (NP)-specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] CD8+ T cell; Dendritic cell; Immunodominance; Influenza virus; Monocyte
PMID: 27859043 DOI: 10.1002/eji.201646523
[PubMed - as supplied by publisher]