tetano
Editor, Senior Moderator
Mol Genet Genomics
. 2024 May 4;299(1):49.
doi: 10.1007/s00438-024-02143-4. Chromosome-Y haplogroups in Asturias (Northern Spain) and their association with severe COVID-19
Mar González-Fernández[SUP] #[/SUP][SUP] 1 [/SUP], Daniel Vázquez-Coto[SUP] #[/SUP][SUP] 2 [/SUP], Guillermo M Albaiceta[SUP] 2 3 4 5 6 [/SUP], Laura Amado-Rodríguez[SUP] 2 3 4 5 6 [/SUP], Marta G Clemente[SUP] 2 7 [/SUP], Lucinda Velázquez-Cuervo[SUP] 2 [/SUP], Claudia García-Lago[SUP] 2 [/SUP], Juan Gómez[SUP] 1 2 5 [/SUP], Eliecer Coto[SUP] 8 9 10 [/SUP]
Affiliations
The main objective of this study was to determine whether the common Y-haplogroups were be associated with the risk of developing severe COVID-19 in Spanish male. We studied 479 patients who required hospitalization due to COVID-19 and 285 population controls from the region of Asturias (northern Spain), They were genotyped for several polymorphisms that define the common European Y-haplogroups. We compared the frequencies between patients and controls aged ≤ 65 and >65 years. There were no different haplogroup frequencies between the two age groups of controls. Haplogroup R1b was less common in patients aged ≤65 years. Haplogroup I was more common in the two patient´s groups compared to controls (p = 0.02). Haplogroup R1b was significantly more frequent among hypertensive patients, without difference between the hypertensive and normotensive controls. This suggested that R1b could increase the risk for severe COVID-19 among male with pre-existing hypertension. In conclusion, we described the Y-haplogroup structure among Asturians. We found an increased risk of severe COVID-19 among haplogroup I carriers, and a significantly higher frequency of R1b among hypertensive patients. These results indicate that Y-chromosome variants could serve as markers to define the risk of developing a severe form of COVID-19.
Keywords: COVID-19; Chromosome-Y; Haplogroups; Hypertension.
. 2024 May 4;299(1):49.
doi: 10.1007/s00438-024-02143-4. Chromosome-Y haplogroups in Asturias (Northern Spain) and their association with severe COVID-19
Mar González-Fernández[SUP] #[/SUP][SUP] 1 [/SUP], Daniel Vázquez-Coto[SUP] #[/SUP][SUP] 2 [/SUP], Guillermo M Albaiceta[SUP] 2 3 4 5 6 [/SUP], Laura Amado-Rodríguez[SUP] 2 3 4 5 6 [/SUP], Marta G Clemente[SUP] 2 7 [/SUP], Lucinda Velázquez-Cuervo[SUP] 2 [/SUP], Claudia García-Lago[SUP] 2 [/SUP], Juan Gómez[SUP] 1 2 5 [/SUP], Eliecer Coto[SUP] 8 9 10 [/SUP]
Affiliations
- PMID: 38704518
- PMCID: PMC11069473
- DOI: 10.1007/s00438-024-02143-4
The main objective of this study was to determine whether the common Y-haplogroups were be associated with the risk of developing severe COVID-19 in Spanish male. We studied 479 patients who required hospitalization due to COVID-19 and 285 population controls from the region of Asturias (northern Spain), They were genotyped for several polymorphisms that define the common European Y-haplogroups. We compared the frequencies between patients and controls aged ≤ 65 and >65 years. There were no different haplogroup frequencies between the two age groups of controls. Haplogroup R1b was less common in patients aged ≤65 years. Haplogroup I was more common in the two patient´s groups compared to controls (p = 0.02). Haplogroup R1b was significantly more frequent among hypertensive patients, without difference between the hypertensive and normotensive controls. This suggested that R1b could increase the risk for severe COVID-19 among male with pre-existing hypertension. In conclusion, we described the Y-haplogroup structure among Asturians. We found an increased risk of severe COVID-19 among haplogroup I carriers, and a significantly higher frequency of R1b among hypertensive patients. These results indicate that Y-chromosome variants could serve as markers to define the risk of developing a severe form of COVID-19.
Keywords: COVID-19; Chromosome-Y; Haplogroups; Hypertension.